期刊
ACS NANO
卷 15, 期 12, 页码 18895-18930出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c08334
关键词
photosensitizers; photothermal agents; photodynamic agents; photoresponsive hydrogels; wound dressing; wound healing; tissue regeneration; multifunctional hydrogels; antibacterial hydrogels
类别
资金
- National Natural Science Foundation of China [51973172]
- Natural Science Foundation of Shaanxi Province [2020JC-03, 2019TD-020]
- State Key Laboratory for Mechanical Behavior of Materials
- State Key Laboratory for World-Class Universities (Disciplines)
- Characteristic Development Guidance Funds for the Central Universities
- Zanjan Pharmaceutical Nanotechnology Research Center [A-12-1143-5, A-12-1143-1, A-12-11433]
- Council for Development of Stem Cell Sciences and Technologies [476758]
- National Institute for Medical Research Development [9900262]
- Iran National Science Foundation [99015911, 4001858]
- Ministry of Health and Medical Education [Pr983902]
Light-based photothermal therapy (PTT) and photo-dynamic therapy (PDT) have great potential in wound healing and infection prevention. Multifunctional photoresponsive hydrogels (MPRHs) combining light and hydrogel advantages are increasingly used in biomedicine, particularly in wound repair. The modulation of bacterial microenvironments to inhibit infection through PTT, PDT, and photothermal/photodynamic synergistic therapy has been discussed.
Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photo-dynamic therapy (PDT) show great application prospects in the prevention of wound infection and promoting wound healing. In addition, hydrogels have shown attractive advantages in the field of wound dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive hydrogels (MPRHs) that integrate the advantages of light and hydrogels are increasingly used in biomedicine, especially in the field of wound repair. However, a comprehensive review of MPRHs for wound regeneration is still lacking. This review first focuses on various types of MPRHs prepared by diverse photosensitizers, photothermal agents (PHTAs) including transition metal sulfide/oxides nanomaterials, metal nanostructure-based PHTAs, carbon-based PHTAs, conjugated polymer or complex-based PHTAs, and/or photodynamic agents (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, and small organic molecule-based PHDAs. We also then discuss how PTT, PDT, and photothermal/photodynamic synergistic therapy can modulate the microenvironments of bacteria to inhibit infection. Overall, multifunctional hydrogels with both therapeutic and tissue regeneration capabilities have been discussed and existing challenges, as well as future research directions in the field of MPRHs and their application in wound management are argued.
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