4.8 Article

Nanotopography Sequentially Mediates Human Mesenchymal Stem Cell-Derived Small Extracellular Vesicles for Enhancing Osteogenesis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment

Zhibo Xie et al.

Summary: This study revealed that PDAC-derived exosomes play a crucial role in modulating the liver microenvironment and promoting liver metastasis. The CD44v6/C1QBP complex delivered by exosomes to hepatic satellite cells leads to activation of insulin-like growth factor 1 signaling molecules and liver fibrosis. High expression of exosomal CD44v6 and C1QBP in PDAC patients is associated with liver metastasis.
Review Endocrinology & Metabolism

RASopathies: The musculoskeletal consequences and their etiology and pathogenesis

John L. Fowlkes et al.

Summary: The RASopathies are clinical syndromes resulting from germline mutations in components of the RAS/MAPK signaling pathway, affecting multiple organs and tissues. This review focuses on how these mutations impact the musculoskeletal system in humans and discusses their genetics and phenotypes in both human and mouse models. It also explores the role of signaling molecules within the RAS/MAPK pathway in normal and abnormal bone biology.
Article Chemistry, Multidisciplinary

Targeting Early Healing Phase with Titania Nanotube Arrays on Tunable Diameters to Accelerate Bone Regeneration and Osseointegration

Long Bai et al.

Summary: The study demonstrates that surface nano-dimensions significantly influence clot formation, and appropriate clot features can manipulate a favorable osteoimmunomodulatory environment, promoting bone regeneration and osseointegration.
Article Engineering, Biomedical

Advanced protein adsorption properties of a novel silicate-based bioceramic: A proteomic analysis

Fanyan Deng et al.

Summary: Silicate bioceramics, particularly CPS, exhibit excellent cytocompatibility and osteogenic activity. Through proteomics technology, it was shown that CPS adsorbed a greater variety and quantity of serum proteins compared to HA, leading to enhanced cell adhesion and bone regeneration. Further analysis revealed the mechanistic insights into how these absorbed proteins mediate cellular behavior and promote osteogenic activity.

BIOACTIVE MATERIALS (2021)

Review Chemistry, Multidisciplinary

Engineered Extracellular Vesicles for Cancer Therapy

Xu Zhang et al.

Summary: Extracellular vesicles (EVs) have shown great potential as a cell-free strategy for cancer therapy, with the ability to be modified and engineered to enhance their therapeutic efficiency and safety. Recent advances have focused on strategies to scale up production, improve cargo-loading, and enhance tumor-targeting of engineered EVs.

ADVANCED MATERIALS (2021)

Article Medicine, Research & Experimental

Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis

Yong He et al.

Summary: This study reveals that the elevation of miR-223 in hepatocytes is due to preferential uptake of miR-223-enriched EVs released from neutrophils and other cells, mediated by LDLR and APOE expression. The internalized EV-derived miR-223 acts to inhibit hepatic inflammatory and fibrogenic gene expression, thereby limiting the progression of NASH.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Cell Biology

Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates

Qingju Li et al.

Summary: This study highlights the key role of sEV miR-486-5p in promoting cardiac angiogenesis. miR-486-5p acts on the fibroblastic MMP19-VEGFA signaling pathway to promote cardiac recovery. Delivery of miR-486-5p-engineered sEVs safely enhanced angiogenesis and cardiac function in a nonhuman primate (NHP) MI model, potentially promoting cardiac repair.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Multidisciplinary Sciences

Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration

Sandra Camarero-Espinosa et al.

Summary: This study presents a dynamic Janus scaffolds fabrication method that can be activated through external application of ultrasound, promoting cell proliferation, matrix deposition and osteogenic differentiation.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs

Zhengnan Yang et al.

Summary: The study found that plasma cells are enriched in high-grade serous ovarian cancers (HGSCs) and are associated with the mesenchymal phenotype switch of tumor cells. Exosome-derived miR-330-3p released by plasma cells induced noncanonical JAM-B expression in nonmesenchymal ovarian cancer cells. Depletion of plasma cells reversed mesenchymal characteristics of ovarian cancer and inhibited in vivo tumor growth.

SCIENCE ADVANCES (2021)

Review Endocrinology & Metabolism

The cytoskeleton and connected elements in bone cell mechano-transduction

Nicole R. Gould et al.

Summary: Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment. Mechanical stress is crucial for bone mass and quality regulation, and understanding how bone cells sense and transduce these mechanical cues is important. While individual cytoskeletal components have been identified as mechano-sensors in bone, the interconnectedness and collaboration of the entire cytoskeleton may be essential for proper bone cell mechano-transduction.
Article Medicine, Research & Experimental

Bone marrow mesenchymal stem cell-derived extracellular vesicles containing miR-497-5p inhibit RSPO2 and accelerate OPLL

Xiaohui Chen et al.

Summary: Muscle and adipose tissue-derived mesenchymal stem cells have high osteogenic potentials and can modulate osteoblast function through releasing extracellular vesicles containing miRNAs. This study found that BMSC-EVs enriched with miR-497-5p could accelerate ossification of the posterior longitudinal ligament (OPLL) by delivering miRNAs to ligament fibroblasts and modulating the RSPO2-mediated Wnt/β-catenin pathway.

LIFE SCIENCES (2021)

Article Multidisciplinary Sciences

Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

Do-Kyun Kim et al.

Summary: In patients with systemic mastocytosis (SM), extracellular vesicles (EVs) released by neoplastic mast cells, containing miRNA-30a and miRNA-23a, are found to inhibit osteoblast differentiation and mineralization, leading to reduced bone mass. This suggests potential novel approaches for managing bone disease in mast cell proliferative disorders.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration

Yizhou Zhu et al.

Summary: The study showed that reducing the scale of honeycomb-like TiO2 structures can activate anti-inflammatory macrophage phenotype, promoting osteogenesis. Among different scales, the 90-nanometer sample demonstrated the most effective outcomes in both in vitro cell culture and in vivo implantation experiments.

SCIENCE ADVANCES (2021)

Article Engineering, Biomedical

Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration

Zhiwei Liao et al.

Summary: The study demonstrates that metformin enhances the release of EVs and changes their protein profile, improving the quality and quantity of MSCs-derived EVs through an autophagy-related pathway. EVs derived from metformin-treated MSCs ameliorate the senescence of intervertebral disc cells, indicating great potential for intervertebral disc regeneration.

BIOMATERIALS (2021)

Article Engineering, Biomedical

A low-temperature-printed hierarchical porous sponge-like scaffold that promotes cell-material interaction and modulates paracrine activity of MSCs for vascularized bone regeneration

Meifei Lian et al.

Summary: The sponge-like scaffolds developed using low temperature deposition modeling (LDM) printing showed significant promotion in cellular behavior and paracrine secretion patterns of MSCs, enhancing multiple regenerative processes such as immunomodulation, angiogenesis, and osteogenesis. This suggests potential applications in tissue engineering and tissue regeneration enhancement through optimization of biomaterial properties to direct the paracrine signaling of MSCs.

BIOMATERIALS (2021)

Review Chemistry, Multidisciplinary

Bone-a-Petite: Engineering Exosomes towards Bone, Osteochondral, and Cartilage Repair

Ho Pan Bei et al.

Summary: Exosomes have emerged as a powerful tool for tissue repair with their complex content and ability to target specific cells, offering potential for enhanced bone, osteochondral, and cartilage regeneration. Engineering applications can further optimize exosomes for various functions through physical, chemical, and biological modulations.
Article Chemistry, Multidisciplinary

Rejuvenation of Senescent Bone Marrow Mesenchymal Stromal Cells by Pulsed Triboelectric Stimulation

Gaocai Li et al.

Summary: The study introduces a new method for rejuvenating senescent bone marrow mesenchymal stromal cells (BMSCs) using pulsed triboelectric stimulation. This approach reverses the senescence phenotypes of aged BMSCs, enhances their proliferation and pluripotency, and rejuvenates them by enhancing MDM2-dependent p53 degradation through pulsed triboelectric stimulation by P-TENG.

ADVANCED SCIENCE (2021)

Article Multidisciplinary Sciences

Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis

Dong Gil You et al.

Summary: Metabolically engineered exosomes have been shown to effectively reprogram macrophages' immune phenotype, demonstrating potential therapeutic efficacy in treating rheumatoid arthritis.

SCIENCE ADVANCES (2021)

Article Engineering, Biomedical

The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans

Joshua C. Doloff et al.

Summary: The surface topography of breast implants influences the immune responses to them, with implants having an average roughness of 4 μm largely suppressing foreign body response and fibrosis.

NATURE BIOMEDICAL ENGINEERING (2021)

Article Cell Biology

Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast-derived extracellular vesicles to promote human bone marrow stem cell osteogenic differentiation

Kenny Man et al.

Summary: EVs, as acellular tools, show promise in tissue engineering by overcoming limitations of cell-based therapies. This study demonstrates that altering osteoblasts' epigenome with the HDAC inhibitor TSA enhances their osteogenic capacity and the therapeutic efficacy of EVs, promoting bone regeneration. The findings suggest a novel approach of harnessing epigenetic regulation to improve EVs' potency in bone repair.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Article Engineering, Biomedical

Enhanced osteogenesis of titanium with nano-Mg(OH)2 film and a mechanism study via whole genome expression analysis

Mengyu Yao et al.

Summary: Bioactive Mg(OH)(2) films developed on titanium surfaces through hydrothermal treatment can improve osteointegration of implants and promote osteogenesis. These films function as platforms for releasing Mg ions, creating nanostructures and weakly alkaline microenvironments, leading to better in vitro and in vivo osteogenesis. Nano-Mg(OH)(2) coated titanium outperforms traditional implants in promoting bone cell biology, showing potential for orthopedic applications.

BIOACTIVE MATERIALS (2021)

Article Cell & Tissue Engineering

Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels

Manuel A. Riquelme et al.

Summary: Mechanical loading activates integrin alpha 5 and alpha V, leading to the opening of connexin 43 (Cx43) hemichannels (HCs) and release of bone anabolic factors. Inhibition of integrin alpha V affects HCs opening and disrupts PI3K/AKT signaling pathway, while integrin alpha 5 activation is dependent on PI3K/AKT activation. Dendritic alpha V is a more sensitive mechanosensor than alpha 5 in activating HCs at low fluid shear stress levels.

BONE RESEARCH (2021)

Article Endocrinology & Metabolism

Circulating miR-181c-5p and miR-497-5p Are Potential Biomarkers for Prognosis and Diagnosis of Osteoporosis

Jianhua Ma et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Materials Science, Biomaterials

Incorporation of F-MWCNTs into electrospun nanofibers regulates osteogenesis through stiffness and nanotopography

Fatemeh Jahanmard et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Cell Biology

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

Emanuela Mensa et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

Article Nanoscience & Nanotechnology

Nanopatterned Titanium Implants Accelerate Bone Formation In Vivo

Andrew I. M. Greer et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Materials Science, Multidisciplinary

Porous 3D Printed Scaffolds For Guided Bone Regeneration In a Rat Calvarial Defect Model

Hoang Phuc Dang et al.

APPLIED MATERIALS TODAY (2020)

Article Engineering, Biomedical

Exosome-integrated titanium oxide nanotubes for targeted bone regeneration

Fei Wei et al.

ACTA BIOMATERIALIA (2019)

Article Biophysics

Smart release of doxorubicin loaded on polyetheretherketone (PEEK) surface with 3D porous structure

Liping Ouyang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

Article Multidisciplinary Sciences

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

Steve Stegen et al.

NATURE COMMUNICATIONS (2018)

Article Medicine, Research & Experimental

Upregulation of miR-210 promotes differentiation of mesenchymal stem cells (MSCs) into osteoblasts

Ali Asgharzadeh et al.

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (2018)

Article Nanoscience & Nanotechnology

Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis

Weiyi Qian et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Review Cell Biology

Stem cell-derived exosomes: A promising strategy for fracture healing

Zi-Chen Hao et al.

CELL PROLIFERATION (2017)

Article Cell Biology

Ras signaling regulates osteoprogenitor cell proliferation and bone formation

Garyfallia Papaioannou et al.

CELL DEATH & DISEASE (2016)

Article Chemistry, Multidisciplinary

Using Nanotopography and Metabolomics to Identify Biochemical Effectors of Multipotency

P. Monica Tsimbouri et al.

ACS NANO (2012)

Article Genetics & Heredity

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

Marjorie J. Lindhurst et al.

NATURE GENETICS (2012)

Article Chemistry, Physical

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

Rebecca J. McMurray et al.

NATURE MATERIALS (2011)

Article Chemistry, Physical

The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder

Matthew J. Dalby et al.

NATURE MATERIALS (2007)

Article Biochemistry & Molecular Biology

Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in Osteoblasts

Takahiro Kanno et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2007)

Article Medicine, Research & Experimental

The hypoxia-inducible factor a pathway couples angiogenesis to osteogenesis during skeletal development

Ying Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)