期刊
ACS NANO
卷 15, 期 10, 页码 16542-16551出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c06130
关键词
dipeptides; diphenylalanine; self-assembly; liquid-cell TEA; ToF-SIMS
类别
资金
- Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource [NSF ECCS-1542205]
- MRSEC program at the Materials Research Center [NSF DMR-1720139]
- International Institute for Nanotechnology (IIN)
- Keck Foundation
- State of Illinois, through the IIN
- National Institutes of Health of the National Institutes of Health [S10OD026871]
- Army Research Office [W911NF-17-1-0326, W911NF-18-1-0359, MURI W911NF-15-1-0568]
- National Science Foundation [CHE-MSN 1905270]
- Human Frontier Science Program [LT000869/2018C]
- Ryan Fellowship
- International Institute for Nanotechnology at Northwestern University
- Clore scholarship
- BSF [2018102]
- GRTF travel grant
- Israel Science Foundation [1732/17]
- DOE Office of Science by Argonne National Laboratory [DE-AC02-06CH11357]
- NSF [0960140]
This study reports the in situ growth of FF nanotubes examined via liquid-cell transmission electron microscopy (LCTEM), revealing the growth mechanism and structure formation process. The radial growth profile of the nanotubes was observed in real-time, with direct observation of the increase in diameter. Post-mortem techniques were used to verify and evaluate the performance of peptides and the assemblies they form.
In this paper, we report the in situ growth of FF nanotubes examined via liquid-cell transmission electron microscopy (LCTEM). This direct, high spatial, and temporal resolution imaging approach allowed us to observe the growth of peptide-based nanofibrillar structures through directional elongation. Furthermore, the radial growth profile of FF nanotubes through the addition of monomers perpendicular to the tube axis has been observed in real-time with sufficient resolution to directly observe the increase in diameter. Our study demonstrates that the kinetics, dynamics, structure formation, and assembly mechanism of these supramolecular assemblies can be directly monitored using LCTEM. The performance of the peptides and the assemblies they form can be verified and evaluated using post-mortem techniques including time-of-flight secondary ion mass spectrometry (ToF-SIMS).
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