4.8 Article

A DNA Nanostructure-Based Neuroprotectant against Neuronal Apoptosis via Inhibiting Toll-like Receptor 2 Signaling Pathway in Acute Ischemic Stroke

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Multidisciplinary

Functionalizing Framework Nucleic-Acid-Based Nanostructures for Biomedical Application

Tao Zhang et al.

Summary: This article discusses the strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) and their potential biomedical applications. tFNAs have the ability to scavenge reactive oxygen species, enhance cellular endocytosis and tissue permeability, and promote cell-material interactions. They can be used to treat inflammatory and degenerative diseases, and also have potential applications in targeted therapies, tissue regeneration, antitumor strategies, and antibacterial treatment through their structural programmability.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Effect of tetrahedral DNA nanostructures on LPS-induced neuroinflammation in mice

Xiao Yang et al.

Summary: Tetrahedral DNA nanostructures (TDNs) alleviate depression-like behavior by regulating the secretion of inflammatory factors.

CHINESE CHEMICAL LETTERS (2022)

Article Engineering, Environmental

Tetrahedral framework nucleic acids act as antioxidants in acute kidney injury treatment

Qi Zhang et al.

Summary: This study demonstrates that tetrahedral framework nucleic acids (tFNAs) exhibit protective effects by relieving oxidative stress and inhibiting apoptosis in treating rhabdomyolysis (RM)-AKI, showing promise as a novel class of antioxidative nanomaterials with excellent antioxidant efficiency, superior structure stability, preferential kidney accumulation, and good biocompatibility.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Chemistry, Multidisciplinary

Treating LRRK2-Related Parkinson's Disease by Inhibiting the mTOR Signaling Pathway to Restore Autophagy

Weitong Cui et al.

Summary: Vitamin B12 is a promising therapeutic option for Parkinson's disease (PD) due to its ability to inhibit LRRK2 activity, but its therapeutic effects are limited by transporter dependence and low brain tissue utilization. Researchers have synthesized VB12-loaded tetrahedral framework nucleic acid (TVC), which has shown to provide better recovery of autophagy and improvement of symptoms in PD models, indicating broad therapeutic potential for PD and similar neurodegenerative diseases.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

The Neuroprotective Effect of MicroRNA-22-3p Modified Tetrahedral Framework Nucleic Acids on Damaged Retinal Neurons Via TrkB/BDNF Signaling Pathway

Jiajie Li et al.

Summary: The study demonstrated that tetrahedral frame nucleic acids (tFNAs) - modified miR-22 can effectively treat glaucoma by activating the TrkB-BDNF signaling pathway to restore damaged retinal neurons' protective function.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage

Wei Fu et al.

Summary: Inhibition of CCR2 expression during the acute phase of ICH polarizes microglia towards a therapeutic subtype, leading to accelerated hematoma absorption, decreased neurological inflammation, and improved neurological function in mice. The nanorobotic tFNA shows promising ability to transfer siCCR2 for treating ICH.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Engineering, Biomedical

The protective effect of tetrahedral framework nucleic acids on periodontium under inflammatory conditions

Mi Zhou et al.

Summary: Tetrahedral framework nucleic acids (tFNAs) show potential in improving the therapeutic effect of periodontitis by reducing inflammation and promoting bone regeneration in periodontal tissue.

BIOACTIVE MATERIALS (2021)

Article Nanoscience & Nanotechnology

Enhanced Neural Regeneration with a Concomitant Treatment of Framework Nucleic Acid and Stem Cells in Spinal Cord Injury

Wenjuan Ma et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Multidisciplinary Sciences

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

Debia Wakhloo et al.

NATURE COMMUNICATIONS (2020)

Review Medicine, General & Internal

Acute Ischemic Stroke

William J. Powers

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Size-Independent Transmembrane Transporting of Single Tetrahedral DNA Nanostructures

Xi Chen et al.

GLOBAL CHALLENGES (2020)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2019 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2019)

Article Clinical Neurology

Global brain inflammation in stroke

Kaibin Shi et al.

LANCET NEUROLOGY (2019)

Article Nanoscience & Nanotechnology

Neuroprotective and Neurotherapeutic Effects of Tetrahedral Framework Nucleic Acids on Parkinson's Disease in Vitro

Weitong Cui et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Biochemistry & Molecular Biology

The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4

Saeedeh Tajalli-Nezhad et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Article Nanoscience & Nanotechnology

Self-Assembled Tetrahedral DNA Nanostructures Promote Neural Stem Cell Proliferation and Neuronal Differentiation

Wenjuan Ma et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Article Nanoscience & Nanotechnology

Neuroprotective Effect of Tetrahedral DNA Nanostructures in a Cell Model of Alzheimer's Disease

Xiaoru Shao et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Article Medicine, Research & Experimental

Protective effect and mechanism of ginsenoside Rg1 in cerebral ischaemia-reperfusion injury in mice

Le Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Medicine, General & Internal

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

G. W. Albers et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Clinical Neurology

Global Burden of Stroke

Mira Katan et al.

SEMINARS IN NEUROLOGY (2018)

Article Endocrinology & Metabolism

Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage

Minshu Li et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Article Multidisciplinary Sciences

High-mobility group box-1 as an autocrine trophic factor in white matter stroke

Jun Young Choi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Multidisciplinary

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

Anil Kumar et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Review Pharmacology & Pharmacy

The application of nanoparticles for neuroprotection in acute ischemic stroke

Lepei Chen et al.

THERAPEUTIC DELIVERY (2017)

Article Nanoscience & Nanotechnology

Designing DNA nanodevices for compatibility with the immune system of higher organisms

Sunaina Surana et al.

NATURE NANOTECHNOLOGY (2015)

Article Cell Biology

The Blood-Brain Barrier

Richard Daneman et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Review Clinical Neurology

Nanotheragnostic Applications for Ischemic and Hemorrhagic Strokes: Improved Delivery for a Better Prognosis

Tarek H. Mouhieddine et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2015)

Article Chemistry, Multidisciplinary

Single-Particle Tracking and Modulation of Cell Entry Pathways of a Tetrahedral DNA Nanostructure in Live Cells

Le Liang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Review Neurosciences

The significance of matrix metalloproteinase (MMP)-2 and MMP-9 in the ischemic stroke

Jacek Kurzepa et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2014)

Review Chemistry, Multidisciplinary

Toxicity of nanomaterials

Shahriar Sharifi et al.

CHEMICAL SOCIETY REVIEWS (2012)

Article Biochemistry & Molecular Biology

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

Takashi Shichita et al.

NATURE MEDICINE (2012)

Review Immunology

Sterile inflammation: sensing and reacting to damage

Grace Y. Chen et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Article Clinical Neurology

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

Mathias Gelderblom et al.

STROKE (2009)

Article Pharmacology & Pharmacy

Experimental models, neurovascular mechanisms and translational issues in stroke research

E. H. Lo

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Article Medicine, Research & Experimental

Pharmacokinetics and biodistribution of nanoparticles

Shyh-Dar Li et al.

MOLECULAR PHARMACEUTICS (2008)

Article Biochemistry & Molecular Biology

Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation

Zhi-Yong Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

Sung-Chun Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Neurosciences

Oncotic pressures opposing filtration across non-fenestrated rat microvessels

RH Adamson et al.

JOURNAL OF PHYSIOLOGY-LONDON (2004)

Review Neurosciences

Mechanisms, challenges and opportunities in stroke

EH Lo et al.

NATURE REVIEWS NEUROSCIENCE (2003)