4.6 Review

Biomaterial Strategies for Restorative Therapies in Parkinson's Disease

期刊

ACS CHEMICAL NEUROSCIENCE
卷 12, 期 22, 页码 4224-4235

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.1c00484

关键词

Parkinson's disease; Biomaterials; Hydrogels; Cell-based therapy; Drug/gene/trophic delivery; Endogenous neural stem cells

资金

  1. Australian Government National Health and Research Council (NHMRC) [GNT1156744]

向作者/读者索取更多资源

Parkinson's disease is a progressive neurological disorder that requires the development of new therapies to stop disease progression and reverse degeneration. Biomaterials play key roles in these therapies.
Parkinson's disease (PD) is a progressive neurological disorder, in which dopaminergic midbrain neurons degenerate, leading to dopamine depletion that is associated with neuronal death. In this Review, we initially describe the pathogenesis of PD and established therapies that unfortunately only delay progression of the disease. With a rapidly escalating incidence in PD, there is an urgent need to develop new therapies that not only halt progression but even reverse degeneration. Biomaterials are playing critical roles in these new therapies which include controlled and site-specific delivery of neurotrophins, increased engraftment of implanted neural stem cells, and redirection of endogenous stem cell populations away from their niche to encourage reparative mechanisms. This Review will therefore cover important design features of biomaterials used in regenerative medicine and tissue engineering strategies targeted at PD.

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