期刊
ACS CHEMICAL NEUROSCIENCE
卷 12, 期 22, 页码 4224-4235出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.1c00484
关键词
Parkinson's disease; Biomaterials; Hydrogels; Cell-based therapy; Drug/gene/trophic delivery; Endogenous neural stem cells
资金
- Australian Government National Health and Research Council (NHMRC) [GNT1156744]
Parkinson's disease is a progressive neurological disorder that requires the development of new therapies to stop disease progression and reverse degeneration. Biomaterials play key roles in these therapies.
Parkinson's disease (PD) is a progressive neurological disorder, in which dopaminergic midbrain neurons degenerate, leading to dopamine depletion that is associated with neuronal death. In this Review, we initially describe the pathogenesis of PD and established therapies that unfortunately only delay progression of the disease. With a rapidly escalating incidence in PD, there is an urgent need to develop new therapies that not only halt progression but even reverse degeneration. Biomaterials are playing critical roles in these new therapies which include controlled and site-specific delivery of neurotrophins, increased engraftment of implanted neural stem cells, and redirection of endogenous stem cell populations away from their niche to encourage reparative mechanisms. This Review will therefore cover important design features of biomaterials used in regenerative medicine and tissue engineering strategies targeted at PD.
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