AD Hypotheses and Suggested Clinical Trials

Alzheimer's disease (AD) is a major neurodegenerative disorder that impairs cognitive reserve impacting activities of daily living. The prime pathological characteristics of AD include the deposition of neurofibrillary tangles of hyperphosphorylated tau (t) proteins, accumulation of amyloid-beta (A beta), and neuronal loss. Expanding literature suggests that oxidative stress (OS) is a vital factor contributing to the pathogenesis of AD such that biometals (e.g., iron, zinc, copper) are believed to play a crucial role in A beta formation and neurodegeneration. Growing evidence indicates the impact of OS in AD, and clinical trials with antioxidative therapeutic interventions are in the frontline of AD research. We discuss various AD hypotheses and associated clinical trials. We present a case for future therapeutic intervention for AD by putting forth postulated hypotheses and trials.

Automated summary

Alzheimer's disease is a major neurodegenerative disorder characterized by the deposition of hyperphosphorylated tau proteins and amyloid-beta, with oxidative stress being a vital factor in its pathogenesis. Antioxidative therapeutic interventions are at the forefront of AD research, suggesting a potential future treatment avenue for the disease.