期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 6, 页码 7680-7689出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c23461
关键词
diabetic wound; glucose-responsive; antioxidation; hydrogel; reactive oxygen species
资金
- National Natural Science Foundation of China [51973243]
- Fundamental Research Funds for the Central Universities [191gzd35]
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06S029]
- Shenzhen Basic Research Project [JCYJ20190807155801657]
- Key international (regional) cooperative research projects of the National Natural Science Foundation of China [5181001045]
In this study, a novel glucose-responsive antioxidant hybrid hydrogel was designed and prepared for enhanced diabetic wound repair. The hydrogel achieved glucose-triggered antioxidant substance release and efficient reactive oxygen species scavenging, leading to improved inflammatory response, accelerated angiogenesis, and promoted diabetic wound healing.
Antioxidant hydrogel has exhibited great potential for diabetic wound treatment. However, it is still a difficult challenge to realize reactive oxygen species (ROS) scavenging in an intelligent manner. Herein, we designed a novel glucose-responsive antioxidant hybrid hydrogel for enhanced diabetic wound repair. In this study, phenylboronic acid (PBA) with unique glucose-sensitivity was modified onto a hyaluronic acid (HA) chain by one-step synthesis, which was then incorporated into a polyethylene glycol diacrylates (PEG-DA) hydrogel matrix to obtain a novel hybrid hydrogel (PEG-DA/HA-PBA). Then, myricetin (MY) molecules with strong antioxidant activity were immobilized into the hybrid hydrogel by the formation of a dynamic borate bond between the polyphenol group of MY and the phenylboronic acid group of HA-PBA. The PEG-DA/HA-PBA/MY (PHM) hybrid hydrogel achieved glucose-triggered MY release, efficient ROS-scavenging (>80.0%), and also reshaped the hostile oxidative wound microenvironment (reduced MDA activity and increased SOD and GSH/GSSG levels). Furthermore, in vitro and in vivo results indicated that the PHM hydrogel platform effectively ameliorated the inflammatory response (decreased IL-6 and increased Il-10 expression), accelerated angiogenesis (increased VEGF and CD 31 expression), and increased tissue remodeling within 20 days, which was better than the nonresponsive PEG-DA/MY (PM) hydrogel platform in promoting diabetic wound healing. All results strongly suggested that this novel glucose-responsive antioxidant hybrid hydrogel platform has great potential in diabetic wound repair.
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