4.8 Article

Cell-Inspired Hydrogel Microcapsules with a Thin Oil Layer for Enhanced Retention of Highly Reactive Antioxidants

期刊

ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 2, 页码 2597-2604

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c20748

关键词

droplet microfluidics; cell-inspired microcapsule; encapsulation; triple emulsion; reactive antioxidants

资金

  1. National Research Foundation of Korea (NRF) - Korea government (MSIT) [2019R1A2C1088927, 2021R1F1A1056481, 2020R1C1C1004642, 2021R1A4A1022206]
  2. NSF through the Harvard MRSEC [DMR-2011754]
  3. National Research Foundation of Korea [2019R1A2C1088927, 2021R1F1A1056481] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

This study reports the development of cell-inspired hydrogel microcapsules that effectively encapsulate and retain antioxidants. The microcapsules have an interstitial oil layer and an ionic gelation hydrogel shell, providing enhanced retention and protection of the antioxidants. Addition of a lipophilic reducing agent in the oil layer enhances the antioxidant activity, and lowering the storage temperature further improves the antioxidant activity.
In nature, individual cells are compartmentalized by a membrane that protects the cellular elements from the surrounding environment while simultaneously equipped with an antioxidant defense system to alleviate the oxidative stress resulting from light, oxygen, moisture, and temperature. However, this mechanism has not been realized in cellular mimics to effectively encapsulate and retain highly reactive antioxidants. Here, we report cell-inspired hydrogel microcapsules with an interstitial oil layer prepared by utilizing triple emulsion drops as templates to achieve enhanced retention of antioxidants. We employ ionic gelation for the hydrogel shell to prevent exposure of the encapsulated antioxidants to free radicals typically generated during photopolymerization. The interstitial oil layer in the microcapsule serves as an stimulus-responsive diffusion barrier, enabling efficient encapsulation and retention of antioxidants by providing an adequate pH microenvironment until osmotic pressure is applied to release the cargo on-demand. Moreover, addition of a lipophilic reducing agent in the oil layer induces a complementary reaction with the antioxidant, similar to the nonenzymatic antioxidant defense system in cells, leading to enhanced retention of the antioxidant activity. Furthermore, we show the complete recovery and even further enhancement in antioxidant activity by lowering the storage temperature, which decreases the oxidation rate while retaining the complementary reaction with the lipophilic reducing agent.

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