期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 47, 页码 55928-55938出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c18311
关键词
mitochondrial targeting; photothermal-chemodynamic therapy; hydroxyl radical; second near-infrared region; photoacoustic imaging
资金
- National Key Research and Development Program of China [2017YFA0205302]
- Natural Science Foundation of Jiangsu Province [BK20191382, BK20200710]
- Key Research and Development Program of Jiangsu [BE2018732]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [YX030003]
MPFPT nanosheets demonstrate enhanced therapeutic efficacy by targeting mitochondria, good photothermal performance, and acceleration of the Fenton reaction, making them promising nanoagents for oncotherapy.
The synergy of chemodynamic therapy (CDT) and photothermal therapy (PTT) can improve anticancer efficacy, while the limited diffusion distance and the short lifetime of (OH)-O-center dot still greatly restrict the therapeutic efficacy of PTT-CDT. Herein, MoS2@PDA-Fe@PEG/TPP (MPFPT) nanosheets (NSs) with mitochondria-targeting ability were reported for enhanced PTT-CDT synergistic oncotherapy. MPFPT NSs were prepared by covalent modification of poly(ethylene glycol) (PEG) and triphenylphosphonium (TPP) on polydopamine (PDA)-Fe3+-coated MoS2 NSs. Co-localization experiments showed that MPFPT NSs can efficiently target mitochondria via the direction of TPP. Moreover, MPFPT NSs have good photothermal performance in the second near-infrared (NIR-II) region and can greatly accelerate the Fenton reaction from H2O2 to generate more hydroxyl radicals ((OH)-O-center dot). In vitro experimental results showed that MPFPT NSs have improved therapeutic efficacy to cancer cells than similar MoS2-based nanoagents without mitochondria-targeting units, which can be attributed to the short distance between mitochondria and MPFPT NSs and the efficient damage of mitochondria by in situ generated (OH)-O-center dot. In the 4T1 tumor-bearing mice model, MPFPT NSs demonstrated significantly enhanced therapeutic efficacy by PTT-CDT, suggesting the superiority of the mitochondria-targeting strategy. This study reveals that mitochondria-targeting MPFPT NSs are promising nanoagents for oncotherapy.
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