期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 47, 页码 55862-55878出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c17054
关键词
hydrogel; nanoparticles; passive targeting; melanoma; metastasis
资金
- DBT-IYBA [BT/09/IYBA/2015/14]
- MHRD IMPRINT 1 [4291, 00275]
- MHRD IMPRINT 2 [4291, 00275]
- DST INSPIRE [INSPIRE/04/2015/00037, DST/TDT/AMT/2017/227]
- Vasudha Foundation [CRG/2020/005069]
- CSIR [09/1001(0044)/2019EMR-1]
- UGC [938/(OBC) (CSIR-UGC NET Dec.2016)]
The study developed a smart nanotransforming hydrogel that transformed in situ into polymeric nanoparticles capable of targeting primary and secondary metastatic tumors. The nanoparticles exhibited pH-responsive drug release and demonstrated efficient inhibition of lung metastases in vivo, compared to chemotherapy.
Metastasis is one of the predisposing factors for cancer-related mortalities worldwide. Patients with advanced cancers (stage IV) receive palliative care with minimal possibility of achieving complete remission. Antibody- based therapeutic modalities are capable of targeting tumors that are confined to a particular location but are ineffective in targeting distant secondary tumors. In the current study, we have developed a smart nanotransforming hydrogel (NTG) that transforms in situ to polymeric nanoparticles ( PA NPs) of 100-150 nm when injected subcutaneously. These nanoparticles targeted the primary and secondary metastatic tumors for up to similar to 5 and similar to 3 days, respectively. The in situ-formed PA NPs also demonstrated a pH-responsive drug release resulting in about similar to 80% release within 100 h at 5.8 pH. When tested in vivo, substantial inhibition of lung metastases was observed compared to chemotherapy, thus demonstrating the efficiency of nanotransforming hydrogels in targeting and inhibiting primary and secondary metastatic tumors.
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