期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 41, 页码 48469-48477出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c16003
关键词
antiviral coatings; self-assembly; peptides; coronavirus; bacteriophage T4
资金
- Ministry of Science and Technology, Israel
- China Scholarship Council [202006760064]
This study demonstrates that peptide-based assemblies can kill viruses and form antiviral coatings on surfaces, potentially reducing the risk of viral transmission in sterile environments.
The COVID-19 pandemic highlighted the importance of developing surfaces and coatings with antiviral activity. Here, we present, for the first time, peptide-based assemblies that can kill viruses. The minimal inhibitory concentration (MIC) of the assemblies is in the range tens of micrograms per milliliter. This value is 2 orders of magnitude smaller than the MIC of metal nanoparticles. When applied on a surface, by drop casting, the peptide spherical assemblies adhere to the surface and form an antiviral coating against both RNA- and DNA-based viruses including coronavirus. Our results show that the coating reduced the number of T4 bacteriophages (DNA-based virus) by 3 log, compared with an untreated surface and 6 log, when compared with a stock solution. Importantly, we showed that this coating completely inactivated canine coronavirus (RNA-based virus). This peptide-based coating can be useful wherever sterile surfaces are needed to reduce the risk of viral transmission.
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