期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 40, 页码 47327-47340出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c10898
关键词
polyetheretherketone (PEEK); tumor inhibition; NIR irradiation; anti-bacteria; bone regeneration
The study developed the first 3D-printed PEEK-based bone scaffold with multiple functions for treating challenging bone diseases. The scaffold, coated with a drug-laden hydroxyapatite layer, utilized graphene nanosheets for on-demand photothermal conversion under laser irradiation. The presence of antibiotics and anti-cancer drugs enhanced treatment efficacy against drug-resistant bacteria and osteosarcoma cells.
In this work, we developed the first 3D-printed polyetheretherketone (PEEK)-based bone scaffold with multi-functions targeting challenging bone diseases such as osteosarcoma and osteomyelitis. A 3D-printed PEEK/graphene nanocomposite scaffold was deposited with a drug-laden (antibiotics and/or anti-cancer drugs) hydroxyapatite coating. The graphene nanosheets within the scaffold served as effective photothermal agents that endowed the scaffold with on-demand photothermal conversion function under near-infrared laser irradiation. The bioactive hydroxyapatite coating significantly boosted the stem cell proliferation in vitro and promoted new bone growth in vivo. The presence of antibiotics and anti-cancer drugs enabled eradication of drug-resistant bacteria and ablation of osteosarcoma cancer cells, the treatment efficacy of which can be further enhanced by on-demand laser-induced heating. The promising results demonstrate the strong potential of our multi-functional scaffold in applications such as bone defect repair and multimodal treatment of osteosarcoma and osteomyelitis.
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