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Chemistry of Lipid Nanoparticles for RNA Delivery Published as part of the Accounts of Chemical Research special issue mRNA Therapeutics

ACCOUNTS OF CHEMICAL RESEARCH (2022)

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Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

Manuel J. Carrasco et al.

Summary: The study reports a method that can predict the pKa of lipid nanoparticles (LNPs) from the structure of the ionizable lipid, and investigates the delivery efficiency and factors influencing LNPs both in vitro and in vivo. It was also found that LNPs with more negative charge lead to higher off-target systemic mRNA expression.

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Summary: This review highlights the recent success of mRNA vaccines in SARS-CoV-2 clinical trials, emphasizing the crucial role of lipid nanoparticles in the delivery systems and providing an analysis of the determinants of lipid nanoparticles' performance in mRNA vaccines.

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Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing

Shuai Liu et al.

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Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver

M. Kim et al.

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Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Michele Schlich et al.

Summary: Ionizable lipid nanoparticles (LNPs) are the most advanced nano-delivery system for therapeutic nucleic acids, with the development of ionizable lipids playing a key role in their success. Overcoming challenges in RNA delivery, such as endosomal escape, is crucial for ensuring the therapeutic activity of RNA molecules. Understanding the mechanisms of endosomal escape and improving cytosolic delivery are important for developing future LNPs with enhanced nucleic acid delivery capabilities.

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Federica Sebastiani et al.

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Encapsulation state of messenger RNA inside lipid nanoparticles

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Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

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Xucheng Hou et al.

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PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production

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Bilayer-Coated Nanoparticles Reveal How Influenza Viral Entry Depends on Membrane Deformability but Not Curvature

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Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

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