Highlighting DEM's Potential to Gauge Mechanistic Attributes of MUPS Tablet and Capsule Formulations

Simulation of pharmaceutical unit operations by the discrete element method (DEM) has elevated our understanding of the impact of single-particle interactions on themselves, and on the entire tablets/powder. Studies in the past have shown how this knowledge helps to mitigate/solve multiple challenges during conventional formulation and process development/modernization/troubleshooting, with minimal use of active drug material. This communication adds to this- highlighting the tool's potential for a rapid preliminary assessment of the mechanistic attributes of multiple unit particle system (MUPS) based tablet and capsule drug products.

Automated summary

Simulation using DEM enhances understanding of single-particle interactions in pharmaceutical unit operations, aiding in mitigating challenges during formulation and process development with minimal use of active drug material. This study highlights the potential of DEM for a rapid preliminary assessment of mechanistic attributes in tablet and capsule drug products based on MUPS.