期刊
HUMAN MOLECULAR GENETICS
卷 25, 期 8, 页码 1663-1676出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddw027
关键词
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资金
- Intramural Research Program of the NIH
- National Cancer Institute
- US Public Health Service [N01-CN-45165, N01-RC-45035, N01-RC-37004]
- National Cancer Institute, Department of Health and Human Services [HHSN261201000006C]
- American Cancer Society
- Intramural Research Program of the National Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics
- National Cancer Institute Surveillance Epidemiology and End Results program
- European Commission [QLK4-CT-2000-00422, FOOD-CT-2006-023103]
- Spanish Ministry of Health [PI11/01810, PI14/01219, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095]
- Marato de TV3 Foundation [051210]
- Agencia de Gestiod'AjutsUniversitarisi de Recerca - Generalitat de Catalunya [2014SRG756]
- NIH [NO1-CO-12400]
- Compagnia di San Paolo-Programma Oncologia
- Federal Office for Radiation Protection [StSch4261, StSch4420]
- Jose Carreras Leukemia Foundation [DJCLS-R12/23]
- German Federal Ministry for Education and Research [BMBF-01-EO-1303]
- Health Research Board, Ireland
- Cancer Research Ireland
- MH CZ - DRO (MMCI) [00209805]
- RECAMO [CZ.1.05/2.1.00/03.0101]
- Fondation de France
- Association de Recherche Contre le Cancer
- Leukemia AMP
- Lymphoma Society Career Development Award
- Bernstein Family Fund for Leukemia and Lymphoma Research
- National Institutes of Health [K08CA134919, CA167552, CA149445, CA098122, CA098566, K07 CA115687, CA186107, CA87969, CA49449]
- National Center for Advancing Translational Science [UL1 TR000135]
- NCI Specialized Programs of Research Excellence (SPORE) in Human Cancer [P50 CA97274]
- Italian Association for Cancer Research (AIRC) [11855]
- VicHealth and Cancer Council Victoria
- Australian NHMRC [209057, 251553, 504711]
- Geoffrey Beene Cancer Research Grant
- Barbara K. Lipman Lymphoma Research Fund [74419]
- Intramural Research Program of the National Cancer Institute, National Institutes of Health and Public Health Service [N01-PC-65064, N01-PC-67008, N01-PC-67009, N01-PC-67010, N02-PC-71105]
- Australian National Health and Medical Research Council [ID990920]
- Cancer Council NSW
- University of Sydney Faculty of Medicine
- Intramural Research Program of the National Cancer Institute
- Division of Cancer Prevention, National Cancer Institute, NIH, DHHS
- NCI, National Institutes of Health [CA1046282, CA154643]
- California Department of Health Services [103885]
- National Cancer Institute's Surveillance, Epidemiology, and End Results Program [HHSN261201000140C, HHSN261201000035C, HHSN261201000034C]
- Centers for Disease Control and Prevention's National Program of Cancer Registries [1U58 DP000807-01]
- Utah Population Database (UPDB)
- Utah Cancer Registry (UCR)
- Huntsman Cancer Institute (HCI)
- HCI Cancer Center [P30 CA42014]
- NIH from the National Cancer Institute SEER Program [HHSN261201000026C]
- Utah State Department of Health
- University of Utah
- Yorkshire Cancer Research
- National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services [HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C]
- [006438]
- [SP23-CT-2005-006438]
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82, P-value = 8.5 x 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51, P-value = 4.0 x 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.
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