相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities
Arianna Bassan et al.
COMPUTATIONAL TOXICOLOGY (2021)
In Silico approaches in carcinogenicity hazard assessment: Current status and future needs
Raymond R. Tice et al.
Computational Toxicology (2021)
Deep Graph Learning with Property Augmentation for Predicting Drug-Induced Liver Injury
Hehuan Ma et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2021)
Combining In Vivo Data with In Silico Predictions for Modeling Hepatic Steatosis by Using Stratified Bagging and Conformal Prediction
Sankalp Jain et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2021)
Development of a Battery of In Silico Prediction Tools for Drug-Induced Liver Injury from the Vantage Point of Translational Safety Assessment
James Rathman et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2021)
DeepDILI: Deep Learning-Powered Drug-Induced Liver Injury Prediction Using Model-Level Representation
Ting Li et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2021)
A Robust, Mechanistically Based In Silico Structural Profiler for Hepatic Cholestasis
James W. Firman et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2021)
Understanding Conditional Associations between ToxCast in Vitro Readouts and the Hepatotoxicity of Compounds Using Rule-Based Methods
Samar Y. Mahmoud et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2020)
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
Katie Paul Friedman et al.
TOXICOLOGICAL SCIENCES (2020)
Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity
Shraddha Thakkar et al.
DRUG DISCOVERY TODAY (2020)
The gut-liver axis in liver disease: Pathophysiological basis for therapy
Agustin Albillos et al.
JOURNAL OF HEPATOLOGY (2020)
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Richard J. Weaver et al.
NATURE REVIEWS DRUG DISCOVERY (2020)
Predictive Models for Human Organ Toxicity Based on In Vitro Bioactivity Data and Chemical Structure
Tuan Xu et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2020)
Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
Elina Drakvik et al.
ENVIRONMENT INTERNATIONAL (2020)
Image Based Liver Toxicity Prediction
Ece Asilar et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data
Linlin Zhao et al.
TOXICOLOGICAL SCIENCES (2020)
The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings
Vera Rogiers et al.
TOXICOLOGY (2020)
Quantitative adverse outcome pathway (qAOP) models for toxicity prediction
Nicoleta Spinu et al.
ARCHIVES OF TOXICOLOGY (2020)
A practical guide to secondary pharmacology in drug discovery
Stephen Jenkinson et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2020)
Comparing Machine Learning Algorithms for Predicting Drug-Induced Liver Injury (DILI)
Eni Minerali et al.
MOLECULAR PHARMACEUTICS (2020)
Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology
Robert Ietswaart et al.
EBIOMEDICINE (2020)
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies
Bryan H. Norman
JOURNAL OF MEDICINAL CHEMISTRY (2020)
An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)
Amy M. Avila et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2020)
New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop
Catherine Mahony et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2020)
Skin sensitization in silico protocol
Candice Johnson et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2020)
Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Caleb Jensen et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2020)
Application of microphysiological systems in biopharmaceutical research and development
Norman C. Peterson et al.
LAB ON A CHIP (2020)
Investigating Cell Type Specific Mechanisms Contributing to Acute Oral Toxicity
Pilar Prieto et al.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2019)
Regulatory assessment and risk management of chemical mixtures: challenges and ways forward
Stephanie K. Bopp et al.
CRITICAL REVIEWS IN TOXICOLOGY (2019)
Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment
Edward J. Perkins et al.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2019)
Genetic toxicology in silico protocol
Catrin Hasselgren et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2019)
Organ-on-chip models: Implications in drug discovery and clinical applications
Rahul Mittal et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence
Aimee M. Deaton et al.
TOXICOLOGICAL SCIENCES (2019)
Today's Challenges to De-Risk and Predict Drug Safety in Human Mind-the-Gap
Richard J. Weaver et al.
TOXICOLOGICAL SCIENCES (2019)
Chemical Hazard Prediction and Hypothesis Testing Using Quantitative Adverse Outcome Pathways
Edward J. Perkins et al.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2019)
A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA)
David E. Hines et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)
Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges
Ying I. Wang et al.
ADVANCED HEALTHCARE MATERIALS (2018)
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms
Chris S. Pridgeon et al.
ARCHIVES OF TOXICOLOGY (2018)
Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
David Hojland Ipsen et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2018)
Advancing Predictive Hepatotoxicity at the Intersection of Experimental, in Silico, and Artificial Intelligence Technologies
Keith Fraser et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2018)
In silico toxicology protocols
Glenn J. Myatt et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2018)
AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks
Maureen E. Pittman et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)
In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices
Jean-Pierre Valentin et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2018)
Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data
Benjamin Alexander-Dann et al.
MOLECULAR OMICS (2018)
Judging the value of 'liver-on-a-chip' devices for prediction of toxicity
Viktoriia Starokozhko et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2017)
The Comparative Toxicogenomics Database: update 2017
Allan Peter Davis et al.
NUCLEIC ACIDS RESEARCH (2017)
Integrating Drug's Mode of Action into Quantitative Structure-Activity Relationships for Improved Prediction of Drug-Induced Liver Injury
Leihong Wu et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
The impact of in silico screening in the discovery of novel and safer drug candidates
Didier Rognan
PHARMACOLOGY & THERAPEUTICS (2017)
Lessons learned from read-across case studies for repeated-dose toxicity
Terry W. Schultz et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)
Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications
Alicia Paini et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017)
Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening (vol 159, pg 124, 2017)
Sreenivasa C. Ramaiahgari et al.
TOXICOLOGICAL SCIENCES (2017)
The current status of exposure-driven approaches for chemical safety assessment: A cross-sector perspective
Fiona Sewell et al.
TOXICOLOGY (2017)
Predicting drug-induced liver injury: The importance of data curation
Eleni Kotsampasakou et al.
TOXICOLOGY (2017)
Potential functional and pathological side effects related to off-target pharmacological activity
James J. Lynch et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2017)
Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs
Huixiao Hong et al.
SCIENTIFIC REPORTS (2017)
Predicting Organ Toxicity Using &ITin Vitro&IT Bioactivity Data and Chemical Structure
Jie Liu et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2017)
In Silico Prediction of Organ Level Toxicity: Linking Chemistry to Adverse Effects
Mark T. D. Cronin et al.
TOXICOLOGICAL RESEARCH (2017)
Drug-Induced Liver Injury: Advances in Mechanistic Understanding That Will Inform Risk Management
M. Mosedale et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2017)
Mechanisms of Drug-Induced Hepatotoxicity
Amina Ibrahim Shehu et al.
CLINICS IN LIVER DISEASE (2017)
Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data
Marlene Thai Kim et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2016)
Reactive Metabolites: Current and Emerging Risk and Hazard Assessments
Richard A. Thompson et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2016)
Computational Models for Human and Animal Hepatotoxicity with a Global Application Scope
Denis Mulliner et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2016)
A History of the Molecular Initiating Event
Timothy E. H. Allen et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2016)
Secondary pharmacology: screening and interpretation of off-target activities - focus on translation
Steven Whitebread et al.
DRUG DISCOVERY TODAY (2016)
A Model to predict severity of drug-induced liver injury in humans
Minjun Chen et al.
HEPATOLOGY (2016)
The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development
Frank D. Sistare et al.
ILAR JOURNAL (2016)
Construction of a predictive model for evaluating multiple organ toxicity
Yu Ri An et al.
MOLECULAR & CELLULAR TOXICOLOGY (2016)
Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes
Mark-Anthony Bray et al.
NATURE PROTOCOLS (2016)
Assessing safety of extractables from materials and leachables in pharmaceuticals and biologics - Current challenges and approaches
Thomas H. Broschard et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2016)
In silico toxicology: computational methods for the prediction of chemical toxicity
Arwa B. Raies et al.
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE (2016)
Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury
Aida Ortega-Alonso et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Predicting Hepatotoxicity Using ToxCast in Vitro Bioactivity and Chemical Structure
Jie Liu et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2015)
Organs-on-chips at the frontiers of drug discovery
Eric W. Esch et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Open TG-GATEs: a large-scale toxicogenomics database
Yoshinobu Igarashi et al.
NUCLEIC ACIDS RESEARCH (2015)
Predicting Human Drug Toxicity and Safety via Animal Tests: Can Any One Species Predict Drug Toxicity in Any Other, and Do Monkeys Help?
Jarrod Bailey et al.
ATLA-ALTERNATIVES TO LABORATORY ANIMALS (2015)
Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies
O. B. Usta et al.
TECHNOLOGY (2015)
How multi-organ microdevices can help foster drug development
Mandy B. Esch et al.
ADVANCED DRUG DELIVERY REVIEWS (2014)
In Vitro and Modelling Approaches to Risk Assessment from the US Environmental Protection Agency ToxCast Programme
Richard Judson et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)
Toward predictive models for drug-induced liver injury in humans: are we there yet?
Minjun Chen et al.
BIOMARKERS IN MEDICINE (2014)
Defining Molecular Initiating Events in the Adverse Outcome Pathway Framework for Risk Assessment
Timothy E. H. Allen et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2014)
In vitro platforms for evaluating liver toxicity
Shyam Sundhar Bale et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2014)
Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
Tom Luedde et al.
GASTROENTEROLOGY (2014)
Hepatic Histological Findings in Suspected Drug-Induced Liver Injury: Systematic Evaluation and Clinical Associations
David E. Kleiner et al.
HEPATOLOGY (2014)
Scientific and Regulatory Reasons for Delay and Denial of FDA Approval of Initial Applications for New Drugs, 2000-2012
Leonard V. Sacks et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
David Cook et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Organogenesis in a dish: Modeling development and disease using organoid technologies
Madeline A. Lancaster et al.
SCIENCE (2014)
Adverse Outcome Pathway (AOP) Development I: Strategies and Principles
Daniel L. Villeneuve et al.
TOXICOLOGICAL SCIENCES (2014)
Adverse Outcome Pathway Development II: Best Practices
Daniel L. Villeneuve et al.
TOXICOLOGICAL SCIENCES (2014)
Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data
Xiao Zhu et al.
TOXICOLOGY (2014)
Progress in computational toxicology
Sean Ekins
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2014)
Modern methodologies and tools for human hazard assessment of chemicals
EFSA JOURNAL (2014)
LiverTox: A website on drug-induced liver injury
Jay H. Hoofnagle et al.
HEPATOLOGY (2013)
Target organ toxicities in studies conducted to support first time in man dosing: An analysis across species and therapy areas
Steve Horner et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2013)
Hazard Evaluation Support System (HESS) for predicting repeated dose toxicity using toxicological categories
Y. Sakuratani et al.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2013)
In silico models for drug-induced liver injury - current status
Katarzyna R. Przybylak et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Molecular mechanisms underlying chemical liver injury
Xinsheng Gu et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2012)
Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms
Johannes Kirchmair et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
Joanne Bowes et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment
Moiz Mumtaz et al.
JOURNAL OF TOXICOLOGY (2012)
Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches
Yen Low et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2011)
FDA-approved drug labeling for the study of drug-induced liver injury
Minjun Chen et al.
DRUG DISCOVERY TODAY (2011)
Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)
Zhichao Liu et al.
PLOS COMPUTATIONAL BIOLOGY (2011)
Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species
Denis Fourches et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2010)
Developing Structure-Activity Relationships for the Prediction of Hepatotoxicity
Nigel Greene et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2010)
Drug-induced liver injury: a clinical update
Marwan Ghabril et al.
CURRENT OPINION IN GASTROENTEROLOGY (2010)
ADVERSE OUTCOME PATHWAYS: A CONCEPTUAL FRAMEWORK TO SUPPORT ECOTOXICOLOGY RESEARCH AND RISK ASSESSMENT
Gerald T. Ankley et al.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2010)
Intrinsic versus Idiosyncratic Drug-Induced Hepatotoxicity-Two Villains or One?
Robert A. Roth et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
TOXICITY TESTING IN THE 21ST CENTURY: A VISION AND A STRATEGY
Daniel Krewski et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity
Stefan Russmann et al.
CURRENT MEDICINAL CHEMISTRY (2009)
Drug-Induced Liver Injury Network (DILIN) Prospective Study Rationale, Design and Conduct
Robert J. Fontana et al.
DRUG SAFETY (2009)
Toxicology for the twenty-first century
Thomas Hartung
NATURE (2009)
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans. Part A: Use of FDA post-market reports to create a database of hepatobiliary and urinary tract toxicities
Carling J. Ursem et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2009)
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities
Edwin J. Matthews et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2009)
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part C: Use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities
Edwin J. Matthews et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2009)
Toxicogenomics in drug discovery and development:: mechanistic analysis of compound/class-dependent effects usign the DrugMatrix® database
Brigitte Ganter et al.
PHARMACOGENOMICS (2006)
In silico techniques for the study and prediction of xenobiotic metabolism:: A review
SA Kulkarni et al.
XENOBIOTICA (2005)
Concordance of the toxicity of pharmaceuticals in humans and in animals
H Olson et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2000)
分享论文
