期刊
HUMAN IMMUNOLOGY
卷 77, 期 6, 页码 476-482出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2015.06.005
关键词
Human mesenchymal stem cells (h-MSCs); TREM-2 (triggering receptor expressed on myeloid cells 2); Toll-like receptors (TLRs)
类别
资金
- Science and Technology Plan Project of Guangdong Province [2010B031600184]
- Key Research Foundation of Guangzhou Branch letter Bureau [1101120184]
- Natural Science Foundation of Guangdong [S2012010010629, S2013010013768]
Activation of the triggering receptor expressed on myeloid cells 2 (TREM-2) regulates myeloid cell function in vitro. However, the failure to detect TREM-2 protein expression in vivo has hampered studies on immunological and other physiological TREM-2 functions. This study demonstrates that TREM-2 is expressed by human mesenchymal stem cells (h-MSCs) and responds to the toll-like receptor (TLR) ligand lipopolysaccharide (LPS). Knockdown of TREM-2 in h-MSCs using a small interfering RNA (siRNA) reduced the expression levels of TLR2, TLR4, and TLR6, inhibited osteogenic, chondrogenic, and adipogenic differentiation under specific induction conditions, and enhanced LPS-evoked inflammatory cytokine production. Thus, activation of TREM-2 may restrain h-MSC immune activation and promote differentiation for tissue repair. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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