期刊
HUMAN GENETICS
卷 135, 期 8, 页码 851-867出版社
SPRINGER
DOI: 10.1007/s00439-016-1683-5
关键词
-
资金
- Fund for Scientific Research (FWO-Flanders, Belgium)
- FWO, University of Antwerp
- Association Belge contre les Maladies Neuro-Musculaires (ABMM)
- EC [2012-305121]
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据