期刊
HUMAN GENETICS
卷 135, 期 3, 页码 359-362出版社
SPRINGER
DOI: 10.1007/s00439-015-1631-9
关键词
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资金
- Bangerter-Rhyner-Stiftung
- COFRA Foundation
- Ebnet-Stiftung
- Gebauer Stiftung
- Hirzel-Callegari Stiftung
- Spendenstiftung Bank Vontobel
- Stiftung FERNE HORIZONTE
Current clinical next-generation sequencing is done by using gene panels and exome analysis, both of which involve selective capturing of target regions. However, capturing has limitations in sufficiently covering coding exons, especially GC-rich regions. We compared whole exome sequencing (WES) with the most recent PCR-free whole genome sequencing (WGS), showing that only the latter is able to provide hitherto unprecedented complete coverage of the coding region of the genome. Thus, from a clinical/technical point of view, WGS is the better WES so that capturing is no longer necessary for the most comprehensive genomic testing of Mendelian disorders.
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