期刊
HUMAN BRAIN MAPPING
卷 37, 期 4, 页码 1361-1374出版社
WILEY
DOI: 10.1002/hbm.23107
关键词
schizophrenia; magnetoencephalography; neuroimaging; electrophysiology; attention
资金
- Medical Research Council [G0601442, MR/M006301/1]
- Medical Research Council UK MEG [MR/K005464/1]
- Dr Hadwen Trust
- Wellcome Trust [WT096002/Z/11/Z]
- MRC [MR/K005464/1, G0901321, MR/M009122/1, MR/J01186X/1, MR/M006301/1] Funding Source: UKRI
- Medical Research Council [MR/M009122/1, G0901321, MR/K005464/1, MR/J01186X/1, MR/M006301/1, G0601442] Funding Source: researchfish
Aberrant salience attribution and cerebral dysconnectivity both have strong evidential support as core dysfunctions in schizophrenia. Aberrant salience arising from an excess of dopamine activity has been implicated in delusions and hallucinations, exaggerating the significance of everyday occurrences and thus leading to perceptual distortions and delusional causal inferences. Meanwhile, abnormalities in key nodes of a salience brain network have been implicated in other characteristic symptoms, including the disorganization and impoverishment of mental activity. A substantial body of literature reports disruption to brain network connectivity in schizophrenia. Electrical oscillations likely play a key role in the coordination of brain activity at spatially remote sites, and evidence implicates beta band oscillations in long-range integrative processes. We used magnetoencephalography and a task designed to disambiguate responses to relevant from irrelevant stimuli to investigate beta oscillations in nodes of a network implicated in salience detection and previously shown to be structurally and functionally abnormal in schizophrenia. Healthy participants, as expected, produced an enhanced beta synchronization to behaviorally relevant, as compared to irrelevant, stimuli, while patients with schizophrenia showed the reverse pattern: a greater beta synchronization in response to irrelevant than to relevant stimuli. These findings not only support both the aberrant salience and disconnectivity hypotheses, but indicate a common mechanism that allows us to integrate them into a single framework for understanding schizophrenia in terms of disrupted recruitment of contextually appropriate brain networks. Hum Brain Mapp 37:1361-1374, 2016. (c) 2016 Wiley Periodicals, Inc.
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