期刊
HUMAN BRAIN MAPPING
卷 37, 期 8, 页码 2894-2903出版社
WILEY
DOI: 10.1002/hbm.23213
关键词
Parkinson's disease; rasagiline; task-based fMRI; free-water diffusion MRI; nigrostriatal regions
资金
- National Institutes of Health
- Department of Defense
- Brain and Behavior Foundation
- NPF
- Michael J. Fox Foundation
- Parkinson Alliance
- Smallwood Foundation
- Bachmann-Strauss Foundation
- Tourette Syndrome Association
- UF Foundation [R01 NS052318, R01 NS075012]
Rasagiline is a monoamine oxidase type B inhibitor that possesses no amphetamine-like properties, and provides symptomatic relief in early and late stages of Parkinson's disease (PD). Data in animal models of PD suggest that chronic administration of rasagiline is associated with structural changes in the substantia nigra, and raise the question whether the structure and function of the basal ganglia could be different in PD patients treated chronically with rasagiline as compared with PD patients not treated with rasagiline. Here, we performed a retrospective cross-sectional magnetic resonance imaging (MRI) study at 3 T that investigated nigrostriatal function and structure in PD patients who had taken rasagiline before testing (similar to 8 months), PD who had not taken rasagiline before testing, and age-matched controls. The two PD groups were selected a priori to not differ significantly in age, sex, disease duration, severity of symptoms, cognitive status, and total levodopa equivalent daily dose of medication. We evaluated percent signal change in the posterior putamen during force production using functional MRI, free-water in the posterior substantia nigra using diffusion MRI, and performance on a bimanual coordination task using a pegboard test. All patients were tested after overnight withdrawal from antiparkinsonian medication. The rasagiline group had greater percent signal change in the posterior putamen, less free-water in the posterior substantia nigra, and better performance on the coordination task than the group not taking rasagiline. These findings point to a possible chronic effect of rasagiline on the structure and function of the basal ganglia in PD. (C) 2016 Wiley Periodicals, Inc.
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