期刊
HUMAN BRAIN MAPPING
卷 37, 期 11, 页码 3707-3720出版社
WILEY
DOI: 10.1002/hbm.23269
关键词
FDG-PET; DWI; disorders of consciousness; function-structure coupling; default mode network
资金
- University of Liege
- University Hospital of Liege
- Belgian National Funds for Scientific Research (FRS-FNRS) the French Speaking Community Concerted Research Action [ARC - 06/11 - 340]
- NSERC discovery grant
- IAP research network of the Belgian Government (Belgian Science Policy) [P7/06]
- European Commission
- James McDonnell Foundation
- Mind Science Foundation
- European space agency (ESA)
- Public Utility Foundation 'Universite Europeenne du Travail'
- Fondazione Europea di Ricerca Biomedica
A vast body of literature exists showing functional and structural dysfunction within the brains of patients with disorders of consciousness. However, the function (fluorodeoxyglucose FDG-PET metabolism)-structure (MRI-diffusion-weighted images; DWI) relationship and how it is affected in severely brain injured patients remains ill-defined. FDG-PET and MRI-DWI in 25 severely brain injured patients (19 Disorders of Consciousness of which 7 unresponsive wakefulness syndrome, 12 minimally conscious; 6 emergence from minimally conscious state) and 25 healthy control subjects were acquired here. Default mode network (DMN) function-structure connectivity was assessed by fractional anisotropy (FA) and metabolic standardized uptake value (SUV). As expected, a profound decline in regional metabolism and white matter integrity was found in patients as compared with healthy subjects. Furthermore, a function-structure relationship was present in brain-damaged patients between functional metabolism of inferior-parietal, precuneus, and frontal regions and structural integrity of the frontal-inferiorparietal, precuneus-inferiorparietal, thalamo-inferioparietal, and thalamofrontal tracts. When focusing on patients, a stronger relationship between structural integrity of thalamo-inferiorparietal tracts and thalamic metabolism in patients who have emerged from the minimally conscious state as compared with patients with disorders of consciousness was found. The latter finding was in line with the mesocircuit hypothesis for the emergence of consciousness. The findings showed a positive function-structure relationship within most regions of the DMN. Hum Brain Mapp 37:3707-3720, 2016. (c) 2016 Wiley Periodicals, Inc.
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