期刊
HUMAN BRAIN MAPPING
卷 37, 期 6, 页码 2210-2222出版社
WILEY-BLACKWELL
DOI: 10.1002/hbm.23167
关键词
anterior temporal lobe; diffusion tensor imaging; healthy subjects; parcellation; structural connectivity
资金
- National Institutes of Health [NINDS R01 NS050915, NIA P50 AG03006, NIA P50 AG023501, NIA P01 AG019724]
- State of California [DHS04-35516]
- Alzheimer's Disease Research Centre of California [03-75271 DHS/ADP/ARCC]
- Larry L. Hillblom Foundation
- John Douglas French Alzheimer's Foundation
- Koret Family Foundation
- Consortium for Frontotemporal Dementia Research
- McBean Family Foundation
The anterior temporal lobes (ATL) have been implicated in a range of cognitive functions including auditory and visual perception, language, semantic knowledge, and social-emotional processing. However, the anatomical relationships between the ATLs and the broader cortical networks that subserve these functions have not been fully elucidated. Using diffusion tensor imaging (DTI) and probabilistic tractography, we tested the hypothesis that functional segregation of information in the ATLs is reflected by distinct patterns of structural connectivity to regions outside the ATLs. We performed a parcellation of the ATLs bilaterally based on the degree of connectivity of each voxel with eight ipsilateral target regions known to be involved in various cognitive networks. Six discrete segments within each ATL showed preferential connectivity to one of the ipsilateral target regions, via four major fiber tracts (uncinate, inferior longitudinal, middle longitudinal, and arcuate fasciculi). Two noteworthy interhemispheric differences were observed: connections between the ATL and orbito-frontal areas were stronger in the right hemisphere, while the consistency of the connection between the ATL and the inferior frontal gyrus through the arcuate fasciculus was greater in the left hemisphere. Our findings support the hypothesis that distinct regions within the ATLs have anatomical connections to different cognitive networks. (C) 2016 Wiley Periodicals, Inc.
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