期刊
HORMONES AND BEHAVIOR
卷 80, 期 -, 页码 1-9出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2016.01.014
关键词
Sex steroid hormones; Estrogen receptor beta; Nervous system; Estradiol; Sexual behavior; Conditional mutagenesis; Male reproduction; Sexual dimorphism
资金
- Contaminants-Ecosystemes-Sante program of the Agence Nationale de la Recherche [ANR-09-CESA-006]
- Reseau Sante Environnement Toxicologie of the Region Ile de France
- CNRS
- INSERM
- UPMC
Estradiol derived from neural aromatization of gonadal testosterone plays a key role in the perinatal organization of the neural circuitry underlying male sexual behavior. The aim of this study was to investigate the contribution of neural estrogen receptor (ER) beta in estradiol-induced effects without interfering with its peripheral functions. For this purpose, male mice lackig ER beta in the nervous system were generated. Analyses of males in two consecutive tests with a time interval of two weeks showed an effect of experience, but not of genotype, on the latencies to the first mount, intromission, pelvic thrusting and ejaculation. Similarly, there was an effect of experience, but not of genotype, on the number of thrusts and mating length. Neural ER beta deletion had no effect on the ability of males to adopt a lordosis posture in response to male mounts, after castration and priming with estradiol and progesterone. Indeed, only low percentages of both genotypes exhibited a low lordosis quotient. It also did not affect their olfactory preference. Quantification of tyrosine hydroxylase- and kisspeptin-immunoreactive neurons in the preoptic area showed unaffected sexual dimorphism of both populations in mutants. By contrast, the number of androgen receptor- and ER alpha-immunoreactive cells was significantly increased in the bed nucleus of stria terminalis of mutant males. These data show that neural ER beta does not play a crucial role in the organization and activation of the neural circuitry underlying male sexual behavior. These discrepancies with the phenotype of global ER beta knockout models are discussed. (C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据