期刊
HISTOCHEMISTRY AND CELL BIOLOGY
卷 146, 期 1, 页码 99-111出版社
SPRINGER
DOI: 10.1007/s00418-016-1427-6
关键词
Tyrosine phosphatase; PTP4A2; PRL-2; CNNM; Magnesium homeostasis
资金
- CIHR/FRSQ training grant in cancer research of the McGill Integrated Cancer Research Training Program [FRN53888]
- CIHR: The PRL-CNNM-Magnesium cascade, a new paradigm in oncogenesis: CIHR [MOP 142497]
- Merck, Sharp & Dohme Corp./McGill Faculty of Medicine Grant for Translational Research program: Characterization of the Complex as a Novel Target for Cancer Therapy [PTP4A2/CNNM3, PT 66481]
- Quebec Breast Cancer Foundation
- Canadian Breast Cancer Research Alliance
The phosphatase of regenerating liver (PRL) is a group of protein tyrosine phosphatases that play a key role in cancer progression and metastasis. We previously showed that PRL-2 modulates intracellular Mg2+ levels and sustains cancer phenotypes by binding to the Mg2+ transporter CNNM3. However, the physiological functions of PRL-2 in animals remain largely unknown. To better understand which cell types are associated with PRL-2 function, we characterized its expression in mouse tissues using a PRL-2 beta-galactosidase reporter mouse model. Our results demonstrated that PRL-2 was ubiquitously expressed, with the highest expression levels observed in the hippocampal pyramidal neurons, ependymal cells, cone and rod photoreceptor cells, endocardium, vascular and bronchial smooth muscle, and collecting ducts in the kidney. On the other hand, PRL-2 expression was undetectable or very low in the parenchymal cells of the liver and pancreas. Our results also indicated that PRL-2 is involved in cell-type-specific Mg2+ homeostasis and that PRL-2 expression is potentially inversely regulated by dietary Mg2+ levels.
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