期刊
HEMIJSKA INDUSTRIJA
卷 70, 期 2, 页码 159-164出版社
ASSOC CHEMICAL ENGINEERS SERBIA
DOI: 10.2298/HEMIND141129023K
关键词
phthalate; plastic material; medical devices; infusion set; peritoneal dialysis set
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [III 41018]
The presence of DEHP in dialysis and infusion sets for peritoneal dialysis and parenteral nutrition, which are made of PVC and other plastic polymeric materials, were investigated. Phthalate determination was carried out by gas chromatography-mass spectrometry method (GC-MS). The results showed that the peritoneal dialysis set (bag and tubing) made of PVC contains DEHP in significant amount, about 31-34%. Solution for peritoneal dialysis which was stored in the investigated PVC bag, contains low amount of DEHP, about 3.72 mu g dm(-3). Infusion bottles which are made of LDPE, also contain DEHP but in lower amount than PVC bags. LDPE bottle for packaging physiological saline solution (0.9% NaCl) showed higher amount of DEHP than LDPE bottle for packaging Ringer's solution. In contrast, solution stored in bottle with lower DEHP level, i.e., Ringer's solution, contained about three times higher concentration of DEHP than physiological saline solution stored in bottle with higher DEHP level. Concentrations of DEHP in Ringer's solution and physiological saline solution are 17.30 and 5.83 mu g dm(-3), respectively. The obtained values are under estimated upper-bound dose of DEHP received by adult patients undergoing procedures of peritoneal dialysis and parenteral nutrition.
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