期刊
FORENSIC SCIENCES RESEARCH
卷 6, 期 3, 页码 240-249出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/20961790.2021.1921945
关键词
Forensic sciences; forensic toxicology; hair analysis; black hair; drug abuse; microsampling; imaging mass spectrometry
资金
- National Natural Science Foundation of China [81772022]
- Shanghai Key Laboratory of Forensic Medicine [17DZ2273200]
- Shanghai Forensic Service Platform [19DZ2292700]
Hair analysis is widely used in forensic toxicology, clinical toxicology, and doping control, gaining more attention in China in the past 30 years. While there are limitations in segmental hair analysis, microsampling and IMS technology may provide a more accurate estimation of drug intake time.
Hair analysis has been mainly used to document drug use history in abusers, drug-facilitated crime cases, doping control analysis and postmortem toxicology in the fields of forensic toxicology, clinical toxicology, and doping control. Hair analysis has also gained more attention in the last 30 years in China. Relevant technology has been promoted as more research has appeared concerning hair analysis, and consensus has been sought among forensic toxicologists regarding aspects such as hair decontamination treatment, detection of abused substances in hair, segmental hair analysis and interpretation of analytical results. However, there are still some limitations in the estimation of drug intake time and frequency by segmental hair analysis due to the different growth cycles evident within a bundle of hairs, the drug incorporation mechanism and sampling errors. Microsampling and imaging mass spectrometry (IMS) technology based on a single hair may be a good choice to estimate drug intake time more accurately. Analysis of hair root samples may also be used to document acute poisoning in postmortem toxicology, and the analysis of the hair shaft can document long-term use of drugs depending on the length of the hair being evaluated.
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