期刊
HELICOBACTER
卷 22, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/hel.12363
关键词
adolescents; Helicobacter pylori infection; iron deficiency; prevalence; serum antibody; serum pepsinogens
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [23590821]
- Grants-in-Aid for Scientific Research [16K01789, 23590821] Funding Source: KAKEN
BackgroundThere have been few reports on Helicobacter pylori (H.pylori) infection in asymptomatic Japanese children and adolescents. We hypothesized that the prevalence of H.pylori infection is very low among Japanese children and that clinical variables such as serum pepsinogen and iron levels are associated with H.pylori infection. Materials and MethodsWe conducted a cross-sectional analysis of a sample of 454 junior high school students aged 12-15years in four areas in Nagano Prefecture. A commercial ELISA kit (E-plate Eiken H.pylori antibody) was used to measure IgG antibody against H.pylori. Serum pepsinogen and iron levels were also measured using standard methods. A urea breath test was performed for seropositive students. ResultsThe overall prevalence of H.pylori was 3.1% (14/454). There were no significant differences in H.pylori prevalence among mountain, rural, and urban areas. The mean level of both serum pepsinogen (PG I) and PG II was significantly increased in the seropositive subjects compared with the seronegative subjects. When the cutoff values for adults (PG I: 70ng/mL and PG I/II ratio: 3) were used, 4 of 14 subjects had PG I 70ng/mL and PG I/II ratio 3. The results of a logistic regression analysis showed that low serum iron levels were significantly associated with H.pylori infection (P=.02). ConclusionsThe prevalence of H.pylori infection is as low as 3% among junior high school students aged 12-15years in Japan. The disappearance of H.pylori is accelerating in Japanese children.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据