Clinical and Laboratory Improvement in Hyperadrenergic Postural Orthostatic Tachycardia Syndrome (POTS) after COVID-19 Infection

Article Medicine, General & Internal

Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies

Melanie Dani et al.

Summary: The COVID-19 pandemic has caused unprecedented morbidity, mortality, and disruption, with a new syndrome known as 'long COVID' emerging among survivors. This syndrome, characterized by debilitating symptoms like breathlessness and palpitations, may be related to autonomic nervous system disruption post-infection. Physicians should recognize and support individuals with 'long COVID' symptoms, with a focus on managing the underlying impaired autonomic physiology.

CLINICAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Immune determinants of COVID-19 disease presentation and severity

Petter Brodin

Summary: The severity of COVID-19 varies by sex and age, and is linked to comorbidities. Differences in immune reactions may go some way to explain this.

NATURE MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome

Pam R. Taub et al.

Summary: This study demonstrates that ivabradine can significantly reduce heart rate, improve patients' quality of life, particularly in terms of physical and social functioning. Additionally, there is a trend of reduction in plasma norepinephrine levels upon standing with ivabradine.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Medicine, General & Internal