期刊
CHINESE HERBAL MEDICINES
卷 13, 期 3, 页码 332-341出版社
ELSEVIER SINGAPORE PTE LTD
DOI: 10.1016/j.chmed.2021.06.005
关键词
inflammation; Lonicerae Japonicae Flos; Lonicerae Flos; network pharmacology
资金
- National Mega-Project for Innovative Drugs [2019ZX09735002]
- Science and Technology Innovation Project of the Chinese Academy of Medical Sciences [2016-I2M-3-015]
Lonicerae Japonicae Flos and Lonicerae Flos exhibit high similarity in treating inflammation, sharing many core targets and biological functions, making them interchangeable in clinical treatment. Organic acids are the main compounds responsible for their anti-inflammatory effects.
Objective: In Chinese herbal medicine (CHM) history, Lonicerae Japonicae Flos and Lonicerae Flos were used clinically as one drug, but now they are admitted as two herbal medicines in Chinese Pharmacopoeia (2010 edition). This study used network pharmacology to investigate whether the two can be used interchangeably for the treatment of inflammatory diseases in TCM clinical practice. Methods: Lonicerae Japonicae Flos and Lonicerae Flos were compared in the inflammation mechanism including core targets, Gene Ontology (GO), pathway and principle chemical components by the method of network pharmacology. Results: Lonicerae Japonicae Flos and Lonicerae Flos shared in six targets accounting for 66.7% of the entire core targets and more than half of the GO terms and pathways are similar. Organic acids are dominent compounds responsible for anti-inflammatory effects. Three of the compounds that bind to core targets including luteolin, quercetin and kaempferol, are shared in both herbs. Conclusion: Due to high similarity between Lonicerae Japonicae Flos and Lonicerae Flos, we believe that they can be used interchangeably for the inflammation in clinical treatment. (C) 2021 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.
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