期刊
NATURAL PRODUCTS AND BIOPROSPECTING
卷 11, 期 4, 页码 379-404出版社
SPRINGERNATURE
DOI: 10.1007/s13659-021-00312-1
关键词
C-H functionalization; alpha-C(sp3)-H arylation; Cyclic carbonyl compounds
资金
- National Science of Foundation of China [81960631]
- Yunnan Fundamental Research Project [202001AS070038]
- Top Young Talent of Ten Thousand Talents Program of Yunnan Province
- Start-up Fund of Yunnan University of Chinese Medicine [2019YZG03]
This review highlighted the significant advances in alpha-C(sp(3))-H arylations of cyclic carbonyl compounds in recent years, including methods, mechanisms, and applications, emphasizing their importance in the total synthesis of natural products.
alpha-C(sp(3))-H arylation is an important type of C-H functionalization. Various biologically significant natural products, chemical intermediates, and drugs have been effectively prepared via C-H functionalization. Cyclic carbonyl compounds comprise of cyclic ketones, enones, lactones, and lactams. The alpha-C(sp(3))-H arylation of these compounds have been exhibited high efficiency in forming C(sp(3))-C(sp(2)) bonds, played a crucial role in organic synthesis, and attracted majority of interests from organic and medicinal communities. This review focused on the most significant advances including methods, mechanism, and applications in total synthesis of natural products in the field of alpha-C(sp(3))-H arylations of cyclic carbonyl compounds in recent years.
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