期刊
NEURODEGENERATIVE DISEASE MANAGEMENT
卷 11, 期 4, 页码 315-328出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nmt-2021-0002
关键词
deep brain stimulation; dystonia; essential tremor; local field potentials; microelectrode recordings; neuromodulation; neurophysiological biomarkers; Parkinson's disease
Intraoperative neurophysiological information can enhance the accuracy of surgical deep brain stimulation lead placement. Specifically targeting pathological activity can optimize DBS therapy. Different synchronization patterns of local field potentials in various frequency bands can correlate with symptoms and response to DBS therapy in Parkinson's disease, dystonia, and essential tremor. Adaptive DBS systems can individualize treatment based on pathological characteristics of neurophysiological signals.
Intraoperative neurophysiological information could increase accuracy of surgical deep brain stimulation (DBS) lead placement. Subsequently, DBS therapy could be optimized by specifically targeting pathological activity. In Parkinson's disease, local field potentials (LFPs) excessively synchronized in the beta band (13-35 Hz) correlate with akinetic-rigid symptoms and their response to DBS therapy, particularly low beta band suppression (13-20 Hz) and high frequency gamma facilitation (35-250 Hz). In dystonia, LFPs abnormally synchronize in the theta/alpha (4-13 Hz), beta and gamma (60-90 Hz) bands. Phasic dystonic symptoms and their response to DBS correlate with changes in theta/alpha synchronization. In essential tremor, LFPs excessively synchronize in the theta/alpha and beta bands. Adaptive DBS systems will individualize pathological characteristics of neurophysiological signals to automatically deliver therapeutic DBS pulses of specific spatial and temporal parameters.
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