期刊
RESPIRATORY INVESTIGATION
卷 59, 期 5, 页码 635-642出版社
ELSEVIER
DOI: 10.1016/j.resinv.2021.06.003
关键词
Coronavirus disease; Side effect; Vaccine; Antibody titer; IgG/IgM antibody
The BNT162b2 mRNA COVID-19 vaccine appears to be safe for Japanese individuals, with an increase in antibody titer observed after two doses. Side effects were reported, with a higher incidence in females compared to males, and a decrease in frequency with age. Further nationwide studies are needed to confirm these findings.
Background: The coronavirus disease (COVID-19) has afflicted large populations worldwide. Although vaccines aroused great expectations, their side effects on Japanese people and the antibody titer transition after vaccination are unclear. Methods: The side effects of the BNT162b2 mRNA COVID-19 vaccine in participants who received vaccination at our center were investigated. Some participants were also surveyed for the antibody titer transition. Results: In this study, 983 and 798 Japanese participants responded to the first and second doses, respectively. Side effects occurred in 757 (77.0%) and 715 participants (90.0%) after the first and second doses, respectively. No Grade 4 side effects occurred. The second dose had significantly more side effects than the first dose (p < 0.001). Side effects occurred after the second dose in 571 female (92.1%) and 178 male participants (80.1%). Female partici-pants had a higher incidence of side effects than the male participants (p < 0.001). A comparison among the age groups showed significant differences (p 1/4 0.018), and the frequency of side effects decreased with age. Twenty-three individuals participated in the survey of antibody titer transition. After the second vaccine dose, the median antibody titers for IgG and IgM were 3.76 and 0.07 AU/mL, respectively. Both IgG and IgM titers showed a significant increase over the study period (p < 0.001). Conclusions: The BNT162b2 mRNA COVID-19 vaccine might be safe for Japanese people, and the antibody titer increased with two doses of vaccination. Larger nationwide studies are warranted to verify these findings. (C) 2021 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.
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