The diagnostic and prognostic value of tumor markers in giant mediastinal endodermal sinus tumor with prolonged survival: Twelve-year follow up after radical resection

We report a case of 16 -year male who presented with nonproductive cough, chest pain, and hemoptysis. His chest -x-ray and computerized tomographic scan (CT) of the thorax with contrast enhancement revealed a large mediastinal mass mostly occupying the left hemithorax. Percutaneous CT scan-guided biopsy of the mediastinal mass was reported as an endodermal sinus tumor (EDST). Serum alpha-fetoprotein levels were markedly raised (120,000 ng/ml). After completion of chemotherapy repeat, CT scan of the thorax revealed a large residual mass. Radical resection of the tumor was carried out. Twelve-year post-surgical resection follow-up with serial serum alpha-fetoprotein (AFP) tumor marker levels and CT scan of the thorax showed no recurrence.

Automated summary

This case report describes a 16-year-old male patient with endodermal sinus tumor (EDST) presenting with nonproductive cough, chest pain, and hemoptysis. Despite initial chemotherapy and subsequent surgical resection, a large residual mass was observed on repeat CT scan, ultimately requiring radical resection of the tumor. Follow-up over 12 years post-surgery showed no recurrence based on serial serum alpha-fetoprotein (AFP) tumor marker levels and thorax CT scans.