Sequential development of ANCA-associated vasculitis and anti-GBM disease: A report of two cases

In case of AAV with kidney involvement, physicians should explore anti-GBM antibodies and be aware of the possible sequential development of AAV, especially with MPO-ANCA, and anti-GBM glomerulonephritis. This sequential disease history is associated with a poor renal outcome, highlighting the need for urgent diagnosis and management.

Automated summary

In cases of AAV with kidney involvement, physicians should investigate anti-GBM antibodies and be vigilant of the potential sequential development of AAV, especially with MPO-ANCA and anti-GBM glomerulonephritis. This sequential disease progression is linked to poor renal outcomes, underscoring the importance of prompt diagnosis and management.