Review Temporal Association Between the COVID-19 Ad26.COV2.S Vaccine and Acute Myocarditis: A Case Report and Literature Review

With the recent approval and widespread administration of the Pfizer-BioNTech, Moderna, and Janssen vaccines worldwide, incidence of severe Coronavirus Disease 2019 (COVID-19) infection has significantly decreased. In spite of their undisputed role in reducing the severity of the disease and reduction of the disease burden in the community, there have been case reports of serious side effects with these vaccines. We aim to describe a case report of myocarditis following administration of the Janssen vaccine in a healthy, young male and review the available literature on COVID-19 vaccine related myocarditis and its possible pathogenesis. This case and literature review notes a temporal association between COVID-19 vaccination and myocarditis. Despite these observations, the benefits of the vaccines far outweigh the risks of possible myocarditis. (C) 2021 Elsevier Inc. All rights reserved.

Automated summary

With the widespread administration of Pfizer-BioNTech, Moderna, and Janssen vaccines, the incidence of severe COVID-19 infection has significantly decreased. However, there have been reports of serious side effects associated with these vaccines. This article describes a case of myocarditis following the administration of the Janssen vaccine in a healthy, young male and reviews the available literature on COVID-19 vaccine-related myocarditis and its possible pathogenesis. Despite the potential risk of myocarditis, the benefits of the vaccines outweigh the risks.