Understanding the Concept of Chronotherapeutics in the Management of Diabetes Mellitus

The circadian rhythms have been controlled with the aid of a circadian clock in the hypothalamus region, which is known as the suprachiasmatic nucleus. Chronotherapeutics, a branch of pharmacotherapeutics, plays a mandatory role in the treatment of various disorders, such as delivering the drug in the correct schedule, correct site, and correct extent and provides benefit to the patients. The chronopharmacological aspects are very much important in the treatment of diabetes mellitus during daytime as the patients' timing of daily activities of body and medicine treatment has an impact on the increase in the glucose levels in the blood. This leads to the fact that the increased risk of obesity and diabetes gets worse, ultimately increasing the rates of cardiovascular diseases and deaths. According to a medical saviour who works on the problems related to diabetes, the level of glucose in plasma changes independently as regard to eating habits and use of insulin and medicines. People suffering from dawn phenomenon are difficult to manage, hence, the basic aim is to detect the functioning of the biological clock of human body and its chronotherapeutic effect on human beings that increases the therapeutic effects and reduces side effects. Keeping these points in mind, an attempt has been made in the present review to discuss the role of chronotherapy in the management of diabetes, various techniques used in formulation and design of chronotherapeutic drug delivery systems and regulatory issues related to chronotherapeutics.

Automated summary

Circadian rhythms are controlled by the circadian clock in the hypothalamus, specifically the suprachiasmatic nucleus, and chronotherapeutics play a crucial role in the treatment of disorders, particularly diabetes. Timing of daily activities and medication has a significant impact on glucose levels in the blood, affecting the risks of obesity, diabetes, cardiovascular diseases, and mortality.