期刊
BRITISH JOURNAL OF OPHTHALMOLOGY
卷 100, 期 3, 页码 436-442出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bjophthalmol-2015-307366
关键词
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资金
- Natural Science Foundation Major International (Regional) Joint Research Project [81320108009]
- Natural Science Foundation [81130019]
- National Natural Science Foundation [31370893, 81270990, 81522013]
- Research Fund for the Doctoral Program of Higher Education of China [20115503110002]
- Ministry of Health [201002019]
- Basic Research Program of Chongqing [cstc2013jcyjC10001]
- Chongqing Key Laboratory of Ophthalmology (CSTC) [2008CA5003]
- National Key Clinical Specialties Construction Program of China
- Health Bureau of Chongqing [2012-1-003]
- Chongqing Science & Technology Platform and Base Construction Program [cstc2014pt-sy10002]
- Fund for PAR-EU Scholars Program Chongqing Outstanding Youth Grant [cstc2014jcyjjq10005]
Background We performed a multistage genome-wide association study of Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population and identified two novel non-human leukocyte antigen candidate regions previously. The aim of the study was to replicate the association of IL23R-C1orf141 and ADO-ZNF365EGR2 with VKH syndrome in four sets of multinational populations in Asia. Method We conducted a candidate genes association study involving 185 patients with VKH syndrome and 287 normal controls from Han Chinese Singaporeans, nonHan Chinese, Thais and Koreans. Genotyping of 16 single nucleotide polymorphisms (SNPs) within IL23R-C1orf141 and ADO-ZNF365-EGR2 loci was performed using the Sequenom MassARRAY system or by Taqman SNP assays. Results Eight SNPs in IL23R-Clorf141 showed an association with VKH syndrome only in Han Chinese Singaporeans (p=8.49x10(-5) to 1.02x10(-3), pcorrection=1.69x10(-4) to 2.04x10(-3)) but not in the other groups tested. One SNP rs1884444 in IL23R-Clorf141 was found to be weakly associated with VKH syndrome in the Han Chinese Singaporeans, but significance was lost following Bonferroni correction for multiple comparisons. Five SNPs in ADO-ZNF365-EGR2 were found to be associated with VKH syndrome in Thai patients with VKH (p=0.014, p(c)=0.028) but not in the other three ethnic groups tested. Conclusions This study confirmed the genetic associations between SNPs in IL23R-C1orf141 and VKH syndrome in Han Chinese Singaporeans but not in other Asian populations. In addition, we also successfully replicated the association of VKH syndrome with ADOZNF365-EGR2 in a Thai population.
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