期刊
THERAPEUTIC DELIVERY
卷 12, 期 9, 页码 671-683出版社
FUTURE SCI LTD
DOI: 10.4155/tde-2021-0039
关键词
gentamicin sulphate; microsuspension; osmolarity; permeation; solidified reverse micellar solution; sustained release
The study successfully developed gentamicin sulphate lipid microsuspensions with high entrapment efficiency and stability, showing superior in vitro release and permeability compared to traditional eye drops, with no irritancy observed.
Aim: Anterior eye segment disorders are treated with eye drops and ointments, which have low ocular bioavailability necessitating the need for improved alternatives. Lipid microsuspension of gentamicin sulphate was developed for the treatment of susceptible eye diseases. Materials & methods: Lipid microsuspensions encapsulating gentamicin sulphate were produced by hot homogenization and evaluated. Ex vivo permeation and ocular irritancy tests were also conducted. Results & conclusion: Stable microsuspensions with high entrapment efficiency and satisfactory osmolarities were obtained. Release studies achieved 49-88% in vitro release at 12 h with sustained permeability of gentamicin compared with conventional gentamicin eye drop (Evril (R)). No irritation was observed following Draize's test. The microsuspensions have great potential as ocular delivery system of gentamicin sulphate.
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