期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 38, 期 11, 页码 1672-1678出版社
WILEY
DOI: 10.1002/hed.24493
关键词
HERG1; potassium channel; oral carcinoma; dysplasia; immunohistochemistry
资金
- Plan Nacional de I+D+I ISCIII [CP13/00013, PI13/00259]
- Red Tematica de Investigacion Cooperativa en Cancer (RTICC), Spain [RD12/0036/0015]
- Fundacion Bancaria Caja de Ahorros de Asturias-IUOPA
- FEDER Funding Program from the European Union
- ISCIII [CD13/00157]
- PFIS ISCIII [FI12/00415]
Background. HERG1 potassium channel plays a critical role in the cell proliferation. Methods. HERG1 protein expression was analyzed by immunohistochemistry (IHC) in 62 patients with oral leukoplakias and 100 patients with oral squamous cell carcinomas (OSCC). HERG1 mRNA levels were assessed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 22 patients with primary head and neck squamous cell carcinoma (HNSCC). Results. Statistically significant associations were found between HERG1 expression and tobacco consumption, disease stage, tumor differentiation, tumor recurrence, and reduced survival. There was no association between HERG1 expression and the risk of progression from oral leukoplakia to OSCC. In addition, a high proportion of tumors (80%) showed increased HERG1 mRNA levels compared to normal mucosa from nononcologic patients. Conclusion. Aberrant HERG1 expression increases as oral tumorigenesis progresses from oral hyperplasia to OSCC. Increased HERG1 mRNA levels were also frequently detected in OSCC and other HNSCC subsites. HERG1 expression emerges as a clinically relevant feature during tumor progression and a potential poor prognostic biomarker for OSCC. (C) 2016 Wiley Periodicals, Inc.
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