期刊
HAEMATOLOGICA
卷 101, 期 11, 页码 1434-1441出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2016.144055
关键词
-
类别
资金
- Pfizer Foundation (Rome, Italy)
- Italian Ministry of University and Research (MIUR, Rome, Italy)-Programma Triennale di Ricerca [1588]
- Instrumentation Laboratory, Milan, Italy
- Fondazione Umberto Veronesi Fellowship
- Italian Ministry of Health [GR-2013-02356060]
- Italian Association for Cancer Research (A.I.R.C.) [AIRC 5x1000, 12237]
Low-grade inflammation is associated with an increased risk of chronic degenerative disease, but its relationship with mortality is less well explored. We aimed at evaluating, at a large epidemiological level, the possible association of low-grade inflammation, as measured by a composite score, with overall mortality risk. We conducted a population-based prospective investigation on 20,337 adult subjects free from major hematological disease and acute inflammatory status, randomly recruited from the general population of the Moli-sani study. A low-grade inflammation score was obtained from the sum of 10-tiles of plasmatic (C-reactive protein) and cellular (leukocyte and platelet counts, granulocyte/lymphocyte ratio) biomarkers of low-grade inflammation; higher levels indicated increased low-grade inflammation. Hazard ratios were calculated using multivariable Cox proportional hazard models with 95% confidence intervals. At the end of follow-up (median 7.6 years), 837 all-cause deaths were recorded. As compared to subjects in the lowest quartile of the low-grade inflammation score, those in the highest category had a significantly increased risk in overall mortality (HR= 1.44; 1.17-1.77), independently of possible confounders, including the presence of chronic diseases and a number of health-related behaviors. The magnitude of the association of low-grade inflammation with mortality was relatively higher in type 2 diabetic patients (HR= 2.90; 1.74-4.84) and in individuals with a history of cardiovascular disease (HR= 2.48; 1.50-4.11) as compared to their counterparts who were free from the disease. In conclusion, an elevated degree of low-grade inflammation, as measured by a composite score of inflammatory biomarkers, is an independent risk factor for total mortality in an apparently healthy adult general population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据