期刊
BRITISH JOURNAL OF NUTRITION
卷 113, 期 1, 页码 1-15出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114514003341
关键词
Dietary Approach to Stop Hypertension diet; Meta-analyses; Hypertension; Dyslipidaemia; Diabetes; Cardiovascular risk
资金
- Ministry of Higher Education and Scientific Research of Iraq
- LiveWell Programme through Lifelong Health and Wellbeing initiative
- Biotechnology and Biological Sciences Research Council
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Medical Research Council
- Chief Scientist Office of the Scottish Government Health Directorates
- National Institute for Health Research/The Department of Health
- Health and Social Care Research & Development of the Public Health Agency (Northern Ireland)
- Wales Office of Research and Development for Health and Social Care
- Welsh Assembly Government [G0900686]
- Medical Research Council [G0900686] Funding Source: researchfish
- MRC [G0900686] Funding Source: UKRI
The Dietary Approach to Stop Hypertension (DASH) is recommended to lower blood pressure (BP), but its effects on cardiometabolic biomarkers are unclear. A systematic review and meta-analysis of randomised controlled trials (RCT) was conducted to determine the effects of the DASH diet on cardiovascular risk factors. Medline, Embase and Scopus databases were searched from inception to December 2013. Inclusion criteria were as follows: (1) DASH diet; (2) RCT; (3) risk factors including systolic and diastolic BE and glucose, HDL, LDL, TAG and total cholesterol concentrations; (4) control group. Random-effects models were used to determine the pooled effect sizes. Meta-regression analyses were carried out to examine the association between effect sizes, baseline values of the risk factors, BMI, age, quality of trials, salt intake and study duration. A total of twenty articles reporting data for 1917 participants were included in the meta-analysis. The duration of interventions ranged from 2 to 21 weeks. The DASH diet was found to result in significant decreases in systolic BP (-5.2mmHg, 95% CI -7.0, -3.4; P<0.001) and diastolic BP (-2.6 mmHg, 95% CI -3.5, -1.7; P<0.001) and in the concentrations of total cholesterol (-0.20 mmol/l, 95% CI -0.31, -0.10; P<0.001) and LDL (-0.10 mmol/l, 95% CI -0.20, -0.01; P=0.03). Changes in both systolic and diastolic BP were greater in participants with higher baseline BP or BMI. These changes predicted a reduction of approximately 13% in the 10-year Framingham risk,score for CVD. The DASH diet improved cardiovascular risk factors and appeared to have greater beneficial effects in subjects with an increased cardiometabolic risk. The DASH diet is an effective nutritional strategy to prevent CVD.
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