期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 52, 期 6, 页码 2497-2504出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-021-05167-6
关键词
Autism spectrum disorders; Amplitude of low-frequency fluctuations; Cerebellum; Functional magnetic resonance imaging
资金
- Youth Program of the National Natural Science Foundation of China [81804198]
- Special Training Program for Young Scientific and Technological Talents of Southwest Medical University
This study found associations between the cerebellum and clinical traits in autism spectrum disorder (ASD) patients, with different cerebellar regions showing correlations with various aspects of SRS scores.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. The associations between the cerebellum and clinical traits remain unclear. We performed amplitude of low-frequency fluctuation (ALFF) analysis to explore the associations between spontaneous brain activity and clinical traits. 361 juvenile ASD patients were included from the ABIDEII database. In the ASD group, the mean ALFF values of cerebellum 4 5 were correlated with SRS awareness and communication. The mean ALFF values of cerebellum 6 and vermis 4 5 were both positively correlated with SRS total, awareness, communication, and motivation. In contrast, the mean ALFF values of vermis 1 2 were negatively correlated with SRS total, awareness, and mannerisms. Our study suggests a role of the cerebellum in functional impairments in ASD.
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