期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 52, 期 8, 页码 3612-3625出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-021-05238-8
关键词
Angelman syndrome; Anxiety; Rating scale; Irritability; Hyperactivity
资金
- Angelman Syndrome Foundation
Anxiety is increasingly being identified in individuals with Angelman syndrome (AS), with aggression being the most common behavioral manifestation of anxiety and separation from caregiver/parent being the most common circumstance. Individuals with a maternal deletion in AS had higher scores on anxiety, irritability, and hyperactivity scales, suggesting the need for adapting existing anxiety rating scales for use in AS. The Pediatric Anxiety Rating Scale was found to best capture behaviors described by caregivers in this study.
Anxiety is being increasingly identified in Angelman syndrome (AS). Qualitative questions and quantitative assessments were used to evaluate for anxiety in 50 subjects with AS. In-person evaluations assessed behaviors concerning for anxiety and circumstances wherein they occurred. Caregivers completed anxiety and other behavioral rating scales. Caregiver responses were categorized and compared to items from anxiety rating scales. The most common behavioral manifestation of anxiety was aggression. The most common circumstance was separation from caregiver/parent. Subjects had elevated scores on anxiety, irritability and hyperactivity scales with lower mean scores among subjects with a maternal deletion. The Pediatric Anxiety Rating Scale best captured behaviors described by caregivers. Existing anxiety scales should be adapted for use in AS.
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