期刊
BRITISH JOURNAL OF NUTRITION
卷 114, 期 7, 页码 1088-1098出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S000711451500210X
关键词
Dietary patterns; Inflammation; FFQ; Cognitive ability
资金
- Age UK's Disconnected Mind project
- Biotechnology and Biological Sciences Research Council
- Medical Research Council
- MRC [G0700704] Funding Source: UKRI
- Medical Research Council [MR/K026992/1, G0700704] Funding Source: researchfish
Epidemiological studies have reported inverse associations between various single healthy diet indices and lower levels of systemic inflammation, but rarely are they examined in the same sample. The aim of the present study was to investigate the potential relationships between biomarkers of systemic inflammation (C-reactive protein (CRP) and fibrinogen) and overall foods (dietary patterns), single foods (fruits and vegetables), and specific nutritive (antioxidants) and non-nutritive (flavonoids) food components in the same narrow-age cohort of older adults. The dietary intake of 792 participants aged 70 years from the Lothian Birth Cohort 1936 was assessed using a 168-item FFQ. Models were adjusted for age, sex, childhood cognitive ability, lifestyle factors and history of disease. Using logistic regression analyses, CRP (normal v. elevated) was favourably associated (at P<0.05) with the 'health-aware' (low-fat) dietary pattern (unstandardised beta = (0.200, OR 0.82, 95% CI 0.68, 0.99) and fruit intake (unstandardised beta = (0.100, OR 0.91, 95% CI 0.82, 0.99), including flavonoid-rich apples (unstandardised beta = (0.456, OR 0.63, 95% CI 0.439, 0.946). Using linear regression analyses, fibrinogen (continuous) was inversely associated (at P < 0.05) with the Mediterranean dietary pattern (standardised beta = (0.100), fruit intake (standardised beta = (0.083), and combined fruit and vegetable intake (standardised beta = (0.084). We observed no association between food components (antioxidant nutrients or specific flavonoid subclasses) and inflammatory markers. In the present cross-sectional study, nutrient-dense dietary patterns were associated with lower levels of systemic inflammation in older people. The results are consistent with dietary guidelines that promote a balanced diet based on a variety of plant-based foods.
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