期刊
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
卷 44, 期 3, 页码 843-853出版社
SPRINGER
DOI: 10.1007/s13246-021-01037-8
关键词
Positron emission tomography; PET; Fluorine-18; F18
A novel method utilizing the He-3(d,p)He-4 nuclear reaction to produce fluorine-18 for PET scans was theoretically evaluated. The theoretical designs involve utilizing helium-3 beams on deuterated plastic targets backed with oxygen-18 heavy-water or super-heavy-water targets. However, practical challenges such as thermal and target degradation effects make the current systems technically infeasible despite the potential advantages over cyclotron-based production.
A novel method of producing fluorine-18 for Positron emission tomography (PET) scan applications is evaluated theoretically. The method is based upon the He-3(d,p)He-4 nuclear reaction from which the protons produced are used to produce fluorine-18 via the O-18(p,n)F-18 reaction. The potential advantage of such a system over cyclotron-based production is of lower input beam energy, which may lower the cost of the system and potentially allow for onsite production. Two theoretical designs were investigated. The first utilizes a helium-3 beam incident on a deuterated plastic target such as Mylar which is backed with an oxygen-18 heavy-water (H2O18) target. The second design utilizes a super-heavy-water (D2O18) target effectively combining both targets into one. Theoretical yield calculations were performed for both designs and the practicalities, primarily those of thermal and target degradation effects were assessed. To produce sufficient fluorine-18 yield a 1 MeV helium-3 beam at 100 mA was simulated. For this beam it was calculated that 310 MBq of fluorine-18 activity, as required to scan a 74 kg patient would be generated in a 69 min or an 18 min production run for the Mylar and super-heavy-water systems respectively. The simulated beam is at 100 kW power and without significant cooling would vaporize the target materials with the melting point of Mylar and boiling point of water calculated to be breached within 0.41 mu s and 0.45 mu s from beam-on. To achieve sufficient fluorine-18 yield the helium-3 beam power had to be increased to impractical levels making the systems technically infeasible.
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