期刊
JCO ONCOLOGY PRACTICE
卷 17, 期 8, 页码 E1225-E1234出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1200/OP.20.01092
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资金
- Seattle Cancer Care Alliance Thoracic Oncology Research (THOR)
- National Cancer Institute [T32CA009515]
The study showed that participation in clinical trials can lead to cost savings for healthcare payers, especially for patients with metastatic non-small-cell lung cancer. Specifically, participation in second-line trials can save healthcare payers $6,663 per month, with a more significant impact on Medicare patients. Further research is needed to explore the differences in cost savings between Medicare and commercial payers.
PURPOSE The costs associated with clinical trial enrollment remain uncertain. We hypothesized that trial participation is associated with decreased total direct medical costs to health care payers in metastatic non-small-cell lung cancer. METHODS In this retrospective cohort study, we linked clinical data from electronic medical records to sociodemographic data from a cancer registry and claims data from Medicare and two private insurance plans. We used a difference-in-difference analysis to estimate mean per patient per month total direct medical costs for patients enrolled on a second-line (2L) trial versus patients receiving standard-of-care 2L systemic therapy. RESULTS Among 70 eligible patients, the difference-in-difference of mean per patient per month total direct medical costs between 2L trial participants and nonparticipants was -$6,663 (P = .01), for a mean savings of $45,308 per patient for the duration of 2L trial therapy. In a secondary analysis by primary insurance payer, this difference-in-difference was -$5,526 (P = .26) for patients with commercial insurance and -$7,432 (P = .01) for patients with Medicare. CONCLUSION Participation in a 2L trial was associated with a $6,663 per month cost savings to health care payers for the duration of trial participation. Further studies are necessary to elucidate differences in cost savings from trial participation for Medicare and commercial payers. If confirmed, these results support health care payer investment in programs to improve clinical trial access and enrollment. (C) 2021 by American Society of Clinical Oncology
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