Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial

Introduction Amyloid-beta (A beta) protein is a major component of the extracellular plaque found in the brains of individuals with Alzheimer's disease (AD). In this study, we investigated the effect of trans-resveratrol as an antagonist treatment for moderate to mild AD, as well as its safety and tolerability. Methods This was a case-control study that enrolled 30 selected patients who had been clinically diagnosed with moderate to mild AD. These patients were randomly divided into two groups, namely, a placebo group (n = 15) and a trans-resveratrol group (n = 15) who received 500 mg trans-resveratrol orally once daily for 52 weeks. Brain magnetic resonance imaging (MRI) examinations were performed on and cerebrospinal fluid (CSF) samples were obtained from all participants before (baseline) and after the study (52 weeks). Enzyme-linked immunosorbent assays were used to determine the levels of plasma A beta 40 and A beta 42 and CSF A beta 40 and A beta 42. Results The results showed that the changes over the study period in the levels of A beta 40 in the blood and CSF of the patients treated with trans-resveratrol were not statistically significant (P > 0.05). In contrast, patients who received placebo showed a significant decrease in A beta 40 levels compared with that at the beginning of the study (CSF A beta 40: P = 0.024, plasma A beta 40: P = 0.036). Analysis of the images on the brain MRI scans revealed that the brain volume of the patients treated with trans-resveratrol was significantly reduced at 52 weeks (P = 0.011) compared with that of patients in the placebo treatment group, Further analysis indicated that the level of matrix metallopeptidase 9 in the CSF of the patients treated with trans-resveratrol at 52 weeks decreased by 46% compared with that of patients in the placebo group (P = 0.033). Conclusion These results indicate that trans-resveratrol has potential neuroprotective roles in the treatment of moderate to mild AD and that its mechanism may involve a reduction in the accumulation and toxicity of A beta in the brain of patients, thereby reducing neuroinflammation.

Automated summary

The study investigated the effect of trans-resveratrol as a treatment for moderate to mild Alzheimer's disease. While the treatment did not significantly impact Aβ40 levels, it showed a decrease in matrix metallopeptidase 9 levels and reduced brain volume compared to the placebo group after 52 weeks. These results suggest potential neuroprotective roles of trans-resveratrol in reducing Aβ accumulation and neuroinflammation in AD patients.