Facile fabrication of monodisperse CoFe2O4 nanocrystals@dopamine@DOX hybrids for magnetic-responsive on-demand cancer theranostic applications

Developing a multifunctional theranostic nanoplatform is vital for dealing with challenging matters correlated with cancers. In this paper, we report an improved facile and relatively green fabrication of highly monodisperse CoFe2O4 nanoparticles with tunable size and morphology. Furthermore, a multifunctional cancer theranostic nanoplatform (CoFe2O4 nanoparticles@dopamine@DOX) was successfully developed for magnetic-responsive on-demand hyperthermia and chemotherapy synergistic theranostics. The proposed nanoplatform exhibits outstanding magneto-triggered hyperthermia efficiency, magnetic-responsive controlled drug delivery capability, enhanced MRI T2-weighted signal, and good biocompatibility. More importantly, the in vivo tumor-bearing mouse model experiments indicated that the CoFe2O4 nanoparticles@dopamine@DOX nanomedicine could realize the functions of magnetic-responsive on-demand hyperthermia and DOX release, which significantly promoted the inactive condition of cancer cells and resulted in obvious tumor regression without evident toxic side effects. According to its facile and green fabrication approach, magneto-triggered high hyperthermia efficiency, magnetic-responsive on-demand cancer therapy, and noninvasive imaging mode, this multifunctional nanoplatform holds great advantages over traditional monotherapy techniques and provides an alternative for the precise clinical treatment of cancer.

Automated summary

This study successfully developed a multifunctional cancer theranostic nanoplatform with high efficiency in magneto-triggered hyperthermia, magnetic-responsive controlled drug delivery, enhanced MRI signal, and good biocompatibility.