期刊
JOURNAL OF POLYMER SCIENCE
卷 59, 期 18, 页码 1994-2013出版社
WILEY
DOI: 10.1002/pol.20210418
关键词
drug delivery; electrospinning; nanofibers; polyhydroxyalkanoates (PHAs); polymers; tissue engineering
资金
- National Natural Science Foundation of China [31900950]
Polyhydroxyalkanoates (PHAs) are natural bio-polymers that serve as excellent biomaterials candidates in tissue engineering and drug delivery. Electrospinning nanofibers can improve the mechanical properties of PHAs and mimic the structure and function of native extracellular matrix, making them widely used in various medical applications.
Differently to most chemically synthesized medical materials, polyhydroxyalkanoates (PHAs) are intracellular carbon and energy storage granules, which is a family of natural bio-polymers synthesized by microorganism's materials. Due to excellent biocompatibility reasonable biodegradability and versatile material difference, PHAs are well medical biomaterials candidates for applications in tissue engineering and drug delivery, including commercial PHB, PHBV, PHBHHx, PHBVHHx, P34HB and few uncommercial PHAs. Electrospinning nanofibers with the size of 10-10,000 nm can improve the mechanical properties and decrease the crystallinity of PHA, meanwhile simulate the structure and function of native extracellular matrix of cells. Hence, PHAs electrospinning nanofibers as engineered scaffolds have been widely used for tissue engineering scaffolds in cardiovascular, vascular, nerve, bone, cartilage and skin; also, as carriers for application in drug delivery system. In this review, we highlight the extraction and properties of medical PHAs from natural or engineered microorganism, and microstructure, current manufacturing techniques and medical applications of electrospinning nanofibers of PHAs. Moreover, the current challenges and prospects of PHAs electrospinning nanofibers are discussed rationally, providing an insight into developing vibrant fields of PHAs electrospinning nanofibers-based biomedicine.
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